Evidence map›Paper›PMID 34759381›Full record

ReviewNature reviews. Genetics2022

Functional genomics data: privacy risk assessment and technological mitigation.

Gamze Gürsoy, Tianxiao Li, Susanna Liu, Eric Ni, Charlotte M Brannon, Mark B Gerstein

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Privacy-Enhancing Technologies in Biomedical Data Science.Annual review of biomedical data science · 2024
    Review
  11. Article
  12. Big data and deep learning for RNA biology.Experimental & molecular medicine · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. FAIR compliant database development for human microbiome data samples.Frontiers in cellular and infection microbiology · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Session Introduction: TOWARDS ETHICAL BIOMEDICAL INFORMATICS: LEARNING FROM OLELO NOEAU, HAWAIIAN PROVERBS.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gamze GürsoyComputational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-1352-8686
Tianxiao LiComputational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-9147-7511
Susanna LiuMolecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7747-5691
Eric NiComputational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4530-0707
Charlotte M BrannonComputational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-4390-2832
Mark B GersteinComputational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA. mark@gersteinlab.org.ORCID http://orcid.org/0000-0002-9746-3719

Funding

Realistic quantification of potential privacy loss from genomic summary resultsK99HG010909 · NHGRI · YALE UNIVERSITY · PI GURSOY, GAMZE · 2020 to 2021
$129k
NHGRI NIH HHS K99 HG010909
6 · The paper itself

Abstract

The generation of functional genomics data by next-generation sequencing has increased greatly in the past decade. Broad sharing of these data is essential for research advancement but poses notable privacy challenges, some of which are analogous to those that occur when sharing genetic variant data. However, there are also unique privacy challenges that arise from cryptic information leakage during the processing and summarization of functional genomics data from raw reads to derived quantities, such as gene expression values. Here, we review these challenges and present potential solutions for mitigating privacy risks while allowing broad data dissemination and analysis.

Indexed as

Genetic PrivacyPrivacyGenomicsHigh-Throughput Nucleotide SequencingRisk Assessment

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.