ArticleChemical science2021
Discovery of SARS-CoV-2 M
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In one paragraph
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
39 citing papers in PubMed.
- The pivotal role of β-lactone stereochemistry in the development of SARS-CoV-2 MProtein science : a publication of the Protein Society · 2026Article
- Differential Impact of Substrate Peptides on Interdomain Interactions in Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease.Computational and structural biotechnology journal · 2026Article
- Targeting Cathepsins in Neurodegeneration: Biochemical Advances.Biomedicines · 2025Review
- A hybrid evolutionary and structural method for AI-guided peptide inhibitor design using AlphaFold and Rosetta.Scientific reports · 2025Article
- Computational and Experimental Study of the Conformational Variation of the Catalytic Residue His41 of the SARS-CoV-2 Main Protease.The journal of physical chemistry. B · 2025Article
- A Reflection on the Use of Molecular Simulation to Respond to SARS-CoV-2 Pandemic Threats.The journal of physical chemistry letters · 2025Review
- Dihydropyrimidine-2-thione derivatives as SARS-CoV-2 main protease inhibitors: synthesis, SAR andRSC advances · 2025Article
- Structure-guided design and triplicate molecular dynamics evaluation of mutant peptide inhibitors targeting SARS-CoV-2 main protease (Mpro).In silico pharmacology · 2025Article
- Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries.Antimicrobial agents and chemotherapy · 2024Article
- Review
- Cyclic βBulletin of the Chemical Society of Japan · 2024Article
- Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein.RSC chemical biology · 2024Article
- Predicting potential SARS-CoV-2 mutations of concern via full quantum mechanical modelling.Journal of the Royal Society, Interface · 2024Article
- Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.Acta crystallographica. Section D, Structural biology · 2024Article
- Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2.Communications chemistry · 2024Article
- A New Advanced Approach: Design and Screening of Affinity Peptide Ligands Using Computer Simulation Techniques.Current topics in medicinal chemistry · 2024Review
- A potential allosteric inhibitor of SARS-CoV-2 main protease (MFrontiers in molecular biosciences · 2024Article
- Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification.Bioorganic & medicinal chemistry · 2023Article
- Free energy along drug-protein binding pathways interactively sampled in virtual reality.Scientific reports · 2023Article
- Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
H T Henry ChanChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research 12 Mansfield Road Oxford OX1 3TA UK fernanda.duartegonzalez@chem.ox.ac.uk christopher.schofield@chem.ox.ac.uk.ORCID https://orcid.org/0000-0001-8838-6136
Marc A MoesserDepartment of Statistics, University of Oxford 24-29 St Giles' Oxford OX1 3LB UK garrett.morris@stats.ox.ac.uk.ORCID https://orcid.org/0000-0001-9882-3272
Rebecca K WaltersCentre for Computational Chemistry, School of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK adrian.mulholland@bristol.ac.uk.ORCID https://orcid.org/0000-0001-7266-2175
Tika R MallaChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research 12 Mansfield Road Oxford OX1 3TA UK fernanda.duartegonzalez@chem.ox.ac.uk christopher.schofield@chem.ox.ac.uk.ORCID https://orcid.org/0000-0003-4989-6410
Rebecca M TwidaleCentre for Computational Chemistry, School of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK adrian.mulholland@bristol.ac.uk.ORCID https://orcid.org/0000-0002-4730-2220
Tobias JohnChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research 12 Mansfield Road Oxford OX1 3TA UK fernanda.duartegonzalez@chem.ox.ac.uk christopher.schofield@chem.ox.ac.uk.ORCID https://orcid.org/0000-0002-6123-595X
Helen M DeeksCentre for Computational Chemistry, School of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK adrian.mulholland@bristol.ac.uk.ORCID https://orcid.org/0000-0003-0411-9343
Tristan Johnston-WoodChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research 12 Mansfield Road Oxford OX1 3TA UK fernanda.duartegonzalez@chem.ox.ac.uk christopher.schofield@chem.ox.ac.uk.ORCID https://orcid.org/0000-0002-5693-270X
Victor MikhailovChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research 12 Mansfield Road Oxford OX1 3TA UK fernanda.duartegonzalez@chem.ox.ac.uk christopher.schofield@chem.ox.ac.uk.ORCID https://orcid.org/0000-0001-6523-8894
Richard B SessionsSchool of Biochemistry, University of Bristol, Medical Sciences Building University Walk Bristol BS8 1TD UK deb.shoemark@bristol.ac.uk.ORCID https://orcid.org/0000-0003-0320-0895
William DawsonRIKEN Center for Computational Science 7-1-26 Minatojima-minami-machi, Chuo-ku Kobe Hyogo 650-0047 Japan.ORCID https://orcid.org/0000-0003-4480-8565
Eidarus SalahChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research 12 Mansfield Road Oxford OX1 3TA UK fernanda.duartegonzalez@chem.ox.ac.uk christopher.schofield@chem.ox.ac.uk.ORCID https://orcid.org/0000-0001-7552-4966
Petra LukacikDiamond Light Source Ltd, Harwell Science and Innovation Campus Didcot OX11 0DE UK.ORCID https://orcid.org/0000-0002-3179-7273
Claire Strain-DamerellDiamond Light Source Ltd, Harwell Science and Innovation Campus Didcot OX11 0DE UK.ORCID https://orcid.org/0000-0003-4964-2090
C David OwenDiamond Light Source Ltd, Harwell Science and Innovation Campus Didcot OX11 0DE UK.ORCID https://orcid.org/0000-0001-5774-8202
Takahito NakajimaRIKEN Center for Computational Science 7-1-26 Minatojima-minami-machi, Chuo-ku Kobe Hyogo 650-0047 Japan.ORCID https://orcid.org/0000-0002-0229-3666
Katarzyna ŚwiderekBiocomp Group, Institute of Advanced Materials (INAM), Universitat Jaume I 12071 Castello Spain.ORCID https://orcid.org/0000-0002-7528-1551
Alessio LodolaFood and Drug Department, University of Parma Parco Area delle Scienze, 27/A 43124 Parma Italy.ORCID https://orcid.org/0000-0002-8675-1002
Vicent MolinerBiocomp Group, Institute of Advanced Materials (INAM), Universitat Jaume I 12071 Castello Spain.ORCID https://orcid.org/0000-0002-3665-3391
David R GlowackiIntangible Realities Laboratory, School of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK.ORCID https://orcid.org/0000-0002-9608-3845
James SpencerIntangible Realities Laboratory, School of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK.ORCID https://orcid.org/0000-0002-4602-0571
Martin A WalshDiamond Light Source Ltd, Harwell Science and Innovation Campus Didcot OX11 0DE UK.ORCID https://orcid.org/0000-0001-5683-1151
Christopher J SchofieldChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research 12 Mansfield Road Oxford OX1 3TA UK fernanda.duartegonzalez@chem.ox.ac.uk christopher.schofield@chem.ox.ac.uk.ORCID https://orcid.org/0000-0002-0290-6565
Luigi GenoveseUniv. Grenoble Alpes, CEA, IRIG-MEM-L_Sim 38000 Grenoble France luigi.genovese@cea.fr.ORCID https://orcid.org/0000-0003-1747-0247
Deborah K ShoemarkSchool of Biochemistry, University of Bristol, Medical Sciences Building University Walk Bristol BS8 1TD UK deb.shoemark@bristol.ac.uk.ORCID https://orcid.org/0000-0002-1240-8463
Adrian J MulhollandCentre for Computational Chemistry, School of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK adrian.mulholland@bristol.ac.uk.ORCID https://orcid.org/0000-0003-1015-4567
Fernanda DuarteChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research 12 Mansfield Road Oxford OX1 3TA UK fernanda.duartegonzalez@chem.ox.ac.uk christopher.schofield@chem.ox.ac.uk.ORCID https://orcid.org/0000-0002-6062-8209
Garrett M MorrisDepartment of Statistics, University of Oxford 24-29 St Giles' Oxford OX1 3LB UK garrett.morris@stats.ox.ac.uk.ORCID https://orcid.org/0000-0003-1731-8405
Funding
Biotechnology and Biological Sciences Research Council BB/L01386X/1Biotechnology and Biological Sciences Research Council BB/M011224/1
Abstract
The main protease (M
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What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.