ArticleAmerican journal of respiratory and critical care medicine2022
Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease.
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Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Patient-centred understanding of quality of life, symptoms, health equity in cystic fibrosis (PULSE-CF): study protocol for an observational study.BMJ open respiratory research · 2026Article
- Z variant heterozygosity in alpha-1 antitrypsin deficiency: disease risk and treatment implications.Orphanet journal of rare diseases · 2026Article
- Alpha-1 Antitrypsin Deficiency-Associated Chronic Obstructive Pulmonary Disease.Medicina (Kaunas, Lithuania) · 2026Review
- Mechanisms and Risk Factors of Cognitive Impairment in COPD.CHEST pulmonary · 2026Article
- Neutrophil Plasticity in Airway Disease: Balancing Damage and Repair.Journal of innate immunity · 2026Review
- Longitudinal Outcomes of Pi*MZ versus Pi*MM Subjects Stratified by Former and Current Smoking Status.Annals of the American Thoracic Society · 2025Article
- Matrix metalloproteinases and disease severity among PI*MZ and PI*ZZ individuals in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) cohort.BMJ open respiratory research · 2025Article
- Mendelian causes of early-onset emphysema: a review of the current literature.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Phenotypic Expression of Respiratory Diseases and Tailored Treatment in Patients with Intermediate Alpha-1 Antitrypsin Deficiency: Evidence from a Retrospective Analysis of a Selected Cohort of Patients.Medicina (Kaunas, Lithuania) · 2025Article
- Assessing inflammatory protein biomarkers in COPD subjects with and without alpha-1 antitrypsin deficiency.Respiratory research · 2025Article
- Increased exacerbations and hospitalizations among PI*MZ compared to PI*MM individuals: an electronic health record analysis.Respiratory research · 2025Article
- Further Insights into Emphysema Progression and Lung Function Decline in MZ Alpha-1 Antitrypsin Deficiency.Annals of the American Thoracic Society · 2025Article
- Longitudinal Outcomes in Pi*MZ Alpha-1 Antitrypsin-Deficient Individuals with Tobacco Smoking History from the SPIROMICS Cohort.Annals of the American Thoracic Society · 2025Article
- LungGENIE: the lung gene-expression and network imputation engine.BMC genomics · 2025Article
- Lung Single-Cell Transcriptomics in Alpha-1 Antitrypsin Deficiency.American journal of respiratory cell and molecular biology · 2024Article
- Alpha-1 Antitrypsin Phenotyping: An Unmet Educational Need of Healthcare Providers.Journal of clinical medicine research · 2024Article
- Alpha-1 Antitrypsin PI M Heterozygotes with Rare Variants: Do They Need a Clinical and Functional Follow-Up?Journal of clinical medicine · 2024Article
- Undiagnosed Alpha-1 Antitrypsin Deficiency and the Perpetuation of Lung Health Inequity.American journal of respiratory and critical care medicine · 2024Article
- Testing Alpha-1 Antitrypsin Deficiency in Black Populations.Advances in respiratory medicine · 2023Review
- Does Chronic Obstructive Pulmonary Disease Originate from Different Cell Types?American journal of respiratory cell and molecular biology · 2023Article
Corrections and comments
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Authors and funding
22 authors at 11 institutions in 2 countries.
Auyon J GhoshChanning Division of Network Medicine and.ORCID 0000-0003-0334-4039
Brian D HobbsChanning Division of Network Medicine and.ORCID 0000-0001-9564-0745
Matthew MollChanning Division of Network Medicine and.
Aabida SaferaliChanning Division of Network Medicine and.
Adel BoueizChanning Division of Network Medicine and.
Jeong H YunChanning Division of Network Medicine and.ORCID 0000-0002-4361-8295
Frank SciurbaDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Lucas BarwickThe Emmes Company, Rockville, Maryland.
Andrew H LimperDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
Kevin FlahertyDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan.
Gerard CrinerDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, Pennsylvania.
Kevin K BrownDepartment of Medicine, National Jewish Health, Denver, Colorado.
Robert WiseDivision of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-8353-2349
Fernando J MartinezDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York; and.
David LomasUniversity College London Respiratory Division of Medicine, University College London, London, United Kingdom.
Peter J CastaldiChanning Division of Network Medicine and.
Vincent J CareyChanning Division of Network Medicine and.
Dawn L DeMeoChanning Division of Network Medicine and.
Michael H ChoChanning Division of Network Medicine and.ORCID 0000-0002-4907-1657
Edwin K SilvermanChanning Division of Network Medicine and.
Craig P HershChanning Division of Network Medicine and.ORCID 0000-0002-1342-4334
COPDGene Investigators
Brigham and Women's Hospital · USHarvard University · USCornell University · USEmmes (United States) · USJohns Hopkins University · USMayo Clinic · USMichigan Medicine · USNational Jewish Health · USTemple University · USUniversity College London · GBUniversity of Pittsburgh · US
Funding
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MSYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASEST32HL007427 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DAWN L DEMEO, Edwin K Silverman · 1985 to 2026
$13.6MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MUsing Integrative Genomics To Identify and Characterize Emphysema-Associated eQTLR01HL124233 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CASTALDI, PETER · 2014 to 2024
$7.1MRare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6MSYSTEMS GENOMICS OF THE ASTHMA-COPD OVERLAP SYNDROMER01HL130512 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HERSH, CRAIG P · 2016 to 2019
$3.5MINTEGRATIVE GENOMICS OF CLINICAL SUBTYPES IN COPDGENER01HL125583 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HERSH, CRAIG P · 2015 to 2018
$3.5MProspective Health Outcomes and Inflammatory Biomarkers Associated with e-Cigarette UseR01HL147326 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CASTALDI, PETER · 2019 to 2021
$1.5MNHLBI NIH HHS HHSN268201500014CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K01 HL157613NHLBI NIH HHS K08 HL136928NHLBI NIH HHS K08 HL141601NHLBI NIH HHS K08 HL146972NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL124233NHLBI NIH HHS R01 HL125583NHLBI NIH HHS R01 HL130512NHLBI NIH HHS R01 HL147326NHLBI NIH HHS T32 HL007427NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL120393NIDDK NIH HHS P30 DK054759NIEHS NIH HHS HHSN268201600032CNIH HHS R01HL124233NIH HHS R01HL125583NIH HHS R01HL130512NIH HHS R01HL147326NIH HHS T32HL007427NIH HHS U01HL089856NIH HHS U01HL089897
Abstract
PubMed holds no abstract for this paper.
Indexed as
GenotypeHeterozygotePhenotypeAdultAgedAged, 80 and overalpha 1-AntitrypsinCase-Control StudiesFemaleGenetic MarkersHumansLongitudinal StudiesMaleMiddle AgedPulmonary Disease, Chronic ObstructiveRespiratory Function Testsalpha 1-AntitrypsinGenetic MarkersSERPINA1 protein, humanalpha-1 antitrypsinchronic obstructive pulmonary diseasemeta-analysisRNA sequencing
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.