Evidence map›Paper›PMID 34763776›Full record

Trial reportJournal of the American College of Cardiology2021

Echocardiographic Ischemic Memory Molecular Imaging for Point-of-Care Detection of Myocardial Ischemia.

Brian P Davidson, James Hodovan, Michael E Layoun, Harsh Golwala, Firas Zahr, Jonathan R Lindner

2 registry-linked trialsAbstract readClinical Trial
In one paragraph

Trial report in Journal of the American College of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07538544 early_phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

MCE Molecular Imaging in Myocarditis

TypeinterventionalSponsorUniversity of VirginiaRan2026 to 2030Enrolled30ConditionsMyocarditis AcuteArmsMyocardial contrast echocardiography molecular imaging for inflammation
NCT07762495 early_phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Echocardiographic Molecular Imaging for POC Detection of Ischemia

TypeinterventionalSponsorUniversity of VirginiaRan2026 to 2030Enrolled80ConditionsAcute Coronary SyndromeArmsMyocardial Contrast Echo (MCE) molecular imaging with Sonazoid
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. The heart of diabetes: unraveling metabolic drivers of cardiomyopathy.Cardiovascular diabetology. Endocrinology reports · 2025
    Review
  4. Review
  5. Acoustic Activation Imaging With Intravenous Perfluoropropane Nanodroplets Results in Selective Bioactivation of the Risk Area.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2024
    Article
  6. Review
  7. Article
  8. Feasibility of sonothrombolysis in the ambulance for ST-elevation myocardial infarction.The international journal of cardiovascular imaging · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Brian P DavidsonKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
James HodovanKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Michael E LayounOregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, USA.
Harsh GolwalaKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Firas ZahrKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Jonathan R LindnerKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, USA. Electronic address: lindnerj@ohsu.edu.

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Targeted CEU Imaging of Atherosclerosis and AngiogenesisR01HL078610 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LINDNER, JONATHAN R · 2004 to 2022
$6.8M
Augmentation of Tissue Perfusion with Ultrasound-mediated CavitationR01HL130046 · NHLBI · UNIVERSITY OF VIRGINIA · PI LINDNER, JONATHAN R · 2016 to 2023
$5.5M
Molecular Imaging of Ischemic Memory with Ultrasound - Transition to HumansRC1HL100659 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LINDNER, JONATHAN R · 2009 to 2010
$979k
NHLBI NIH HHS R01 HL078610NHLBI NIH HHS R01 HL130046NHLBI NIH HHS RC1 HL100659NIH HHS P51 OD011092
6 · The paper itself

Abstract

backgroundNoninvasive molecular imaging of recent ischemia can potentially be used to diagnose acute coronary syndrome (ACS) with high accuracy.

objectivesThe authors hypothesized that bedside myocardial contrast echocardiography (MCE) ischemic memory imaging could be achieved with phosphatidylserine microbubbles (MB

methodsA dose-finding study was performed in healthy volunteers (n = 17) to establish optimal MB

resultsBased on dose-finding studies, 0.10 or 0.15 mL of MB

conclusionsMolecular imaging with point-of-care echocardiography and MB

Indexed as

MicrocirculationPoint-of-Care SystemsAcute Coronary SyndromeAdultAgedAlgorithmsContrast MediaCoronary AngiographyDose-Response Relationship, DrugEchocardiographyFemaleHealthy VolunteersHumansInfusions, IntravenousKineticsMaleContrast Mediaechocardiographyischemiamolecular imaging

Identifiers

PMID34763776
PMCPMC8597917

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.