ArticleNature nanotechnology2021
A lysosome-targeted DNA nanodevice selectively targets macrophages to attenuate tumours.
Abstract read
In one paragraph
Article in Nature nanotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 102 citations in OpenAlex.
- Opportunities and challenges for cancer immunotherapy based on antigen cross-presentation.Annals of medicine · 2026Review
- Chronic inflammation-responsive hydrogel restores myeloid-T cell crosstalk to reinvigorate antitumor immunity against metastatic colorectal cancer.Bioactive materials · 2026Article
- Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor-Associated Macrophages.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Targeting lysosome-dependent cell death in cancer: towards therapeutic strategies.Biomarker research · 2026Review
- A nucleic acid labeling chemistry reveals surface DNA on exosomes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Loss of Cathepsin Z enhances pro-inflammatory macrophage responses and promotes tissue regeneration.Disease models & mechanisms · 2026Article
- Mitochondria in situ releasing corosolic acid enhanced antitumor effects via activating mitophagy in castration-resistant prostate cancer.Journal of translational medicine · 2026Article
- Spatiotemporal dynamics of radioresistance: decoding macrophage-driven radioprotective niches through temporal-spatial reprogramming.Molecular cancer · 2026Review
- Nanoparticles that modulate immune cells - an important strategy for the future treatment of tumors.Frontiers in immunology · 2026Review
- Targeting Lysosomes for Enhanced Anti-Cancer Therapeutics and Immune Response.International journal of biological sciences · 2026Review
- Aptamers targeting immune checkpoints for tumor immunotherapy: a comprehensive review.Frontiers in oncology · 2026Review
- A nucleic acid labeling chemistry reveals surface DNA on exosomes.bioRxiv : the preprint server for biology · 2025Article
- A Nanomodulator Enhances Radiotherapy-Induced In Situ Cancer Vaccine by Promoting Antigen-Presenting of Tumor-Associated Macrophage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A nanovaccine targeting cancer stem cells and bulk cancer cells for postoperative cancer immunotherapy.Nature nanotechnology · 2025Article
- Aptamers Targeting Immune Checkpoints for Tumor Immunotherapy.Pharmaceutics · 2025Review
- Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer.Journal for immunotherapy of cancer · 2025Article
- Programmable DNA-based biomaterials for bone tissue engineering.Fundamental research · 2025Review
- Exploring the Subcellular Localization and Degradation of Spherical Nucleic Acids Using Fluorescence Lifetime Imaging Microscopy.ACS nano · 2025Article
- FRET-based reporter assesses lysosomal DNA-degradation ability in live cells.Sensors and actuators reports · 2025Article
- Protease regulation of tumor-immune cell symbiosis.Trends in cancer · 2025Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Chang CuiCommittee on Cancer Biology, The University of Chicago, Chicago, IL, USA.
Kasturi ChakrabortyBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-0635-9028
Xu Anna TangBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Kelly Q SchoenfeltBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Alexandria HoffmanBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Ariane BlankBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Blake McBethBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Natalie PulliamDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Catherine A ReardonBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Swati A KulkarniDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-4213-0933
Tomas VaisarUW Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7406-6606
Andrea BallabioTelethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.ORCID http://orcid.org/0000-0003-1381-4604
Yamuna KrishnanDepartment of Chemistry, The University of Chicago, Chicago, IL, USA. yamuna@uchicago.edu.ORCID http://orcid.org/0000-0001-5282-8852
Lev BeckerCommittee on Cancer Biology, The University of Chicago, Chicago, IL, USA. levb@uchicago.edu.
University of Chicago · USNorthwestern University · USBaylor College of Medicine · USUniversity of Washington · US
Funding
'Metabolically Activated' Macrophages in Obesity and Insulin ResistanceR01DK102960 · NIDDK · UNIVERSITY OF CHICAGO · PI BECKER, LEV · 2015 to 2024
$4.4MChicago EYES (Educators and Youth Enjoy Science) on Cancer {2024}R25CA221767 · NCI · UNIVERSITY OF CHICAGO · PI Mary Eileen Dolan, Megan Mekinda · 2017 to 2026
$2.8MNCI NIH HHS R25 CA221767
Abstract
Activating CD8
Indexed as
AnimalsAntigensBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCD8-Positive T-LymphocytesCell ProliferationCombined Modality TherapyCross-PrimingCyclophosphamideDNAFemaleHumansImmunityLysosomesMiceMice, Inbred C57BLNanoparticlesAntigensBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCyclophosphamideDNATcfeb protein, mouse
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.