ArticleNature neuroscience2021
A data-driven framework for mapping domains of human neurobiology.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- GINNA, a 33 resting-state networks atlas with meta-analytic decoding-based cognitive characterization.Communications biology · 2025Pooled it
- Evidence for domain-general arousal from semantic and neuroimaging meta-analyses reconciles opposing views on arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Pooled it
- Refining RDoC Using Individual-Level Task fMRI Factor Models Reveals Reproducible and Clinically Relevant Brain-Wide Motifs.bioRxiv : the preprint server for biology · 2026Article
- A geometry aware framework enhances noninvasive mapping of whole human brain dynamics.Nature biomedical engineering · 2026Article
- An Interactive Brain Atlas of Knowledge.bioRxiv : the preprint server for biology · 2026Article
- Beyond the dichotomy between controlled and naturalistic paradigms: modeling psychological constructs in cognitive neuroscience.Frontiers in psychology · 2026Article
- Peaks2Image: Reconstructing fMRI maps from stereotactic coordinates to enhance cognitive meta-analysis.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Article
- Comprehensive mapping of cognitive and emotion networks in stress, anxiety, and depression implicates the precuneus as a critical hub.Research square · 2025Article
- From Correlation to Causation: Understanding Episodic Memory Networks.Neuroscience bulletin · 2025Review
- A dimensional approach to psychosis: identifying cognition, depression, and thought disorder factors in a clinical sample.Schizophrenia (Heidelberg, Germany) · 2025Article
- A data-driven latent variable approach to validating the research domain criteria framework.Nature communications · 2025Article
- The Transition From Homogeneous to Heterogeneous Machine Learning in Neuropsychiatric Research.Biological psychiatry global open science · 2025Review
- The morphospace of the brain-cognition organisation.Nature communications · 2024Article
- Centering cognitive neuroscience on task demands and generalization.Nature neuroscience · 2024Review
- Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies.Nature biomedical engineering · 2024Article
- Enhancing post-traumatic stress disorder patient assessment: leveraging natural language processing for research of domain criteria identification using electronic medical records.BMC medical informatics and decision making · 2024Article
- Never-Ending Learning for Explainable Brain Computing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Enhancing post-traumatic stress disorder patient assessment: Leveraging Natural Language Processing for Research of Domain Criteria Identification using electronic medical records.Research square · 2024Article
- A critical evaluation of QIDS-SR-16 using data from a trial of psilocybin therapy versus escitalopram treatment for depression.Journal of psychopharmacology (Oxford, England) · 2023Article
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4 authors at 2 institutions in 1 country.
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Abstract
Functional neuroimaging has been a mainstay of human neuroscience for the past 25 years. Interpretation of functional magnetic resonance imaging (fMRI) data has often occurred within knowledge frameworks crafted by experts, which have the potential to amplify biases that limit the replicability of findings. Here, we use a computational approach to derive a data-driven framework for neurobiological domains that synthesizes the texts and data of nearly 20,000 human neuroimaging articles. Across multiple levels of domain specificity, the structure-function links within domains better replicate in held-out articles than those mapped from dominant frameworks in neuroscience and psychiatry. We further show that the data-driven framework partitions the literature into modular subfields, for which domains serve as generalizable prototypes of structure-function patterns in single articles. The approach to computational ontology we present here is the most comprehensive characterization of human brain circuits quantifiable with fMRI and may be extended to synthesize other scientific literatures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.