Evidence map›Paper›PMID 34768822›Full record

ArticleInternational journal of molecular sciences2021

Viral Infection Drives the Regulation of Feeding Behavior Related Genes in

David Muñoz, Ricardo Fuentes, Beatriz Carnicero, Andrea Aguilar, Nataly Sanhueza, Sergio San-Martin, Cristian Agurto, Andrea Donoso, Leonardo E Valdivia, Jesús M Miguez and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Editorial: Fish Welfare in Aquaculture and Research-Where Are We Going?Animals : an open access journal from MDPI · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

David MuñozCentro de Biotecnología, Departamento de Oceanografía, Universidad de Concepción, Concepción 4030000, Chile.
Ricardo FuentesDepartamento de Biología Celular, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4030000, Chile.
Beatriz CarniceroCentro de Biotecnología, Departamento de Oceanografía, Universidad de Concepción, Concepción 4030000, Chile.
Andrea AguilarCentro de Biotecnología, Departamento de Oceanografía, Universidad de Concepción, Concepción 4030000, Chile.
Nataly SanhuezaCentro de Biotecnología, Departamento de Oceanografía, Universidad de Concepción, Concepción 4030000, Chile.ORCID 0000-0002-1761-1268
Sergio San-MartinGrupo Interdisciplinario en Biotecnología Marina (GIBMAR), Centro de Biotecnología, Departamento de Ciencia y Tecnología de los Alimentos, Facultad de Farmacia, Universidad de Concepción, Concepción 4030000, Chile.
Cristian AgurtoGrupo Interdisciplinario en Biotecnología Marina (GIBMAR), Centro de Biotecnología, Departamento de Ciencia y Tecnología de los Alimentos, Facultad de Farmacia, Universidad de Concepción, Concepción 4030000, Chile.
Andrea DonosoGrupo Interdisciplinario en Biotecnología Marina (GIBMAR), Centro de Biotecnología, Departamento de Ciencia y Tecnología de los Alimentos, Facultad de Farmacia, Universidad de Concepción, Concepción 4030000, Chile.
Leonardo E ValdiviaCenter for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago 7500000, Chile.
Jesús M MiguezCentro de Investigación Marina, Laboratorio de Fisiología Animal, Departamento de Bioloxía Funcional e Ciencias de la Salud, Facultad de Biología, Universidade de Vigo, 36310 Vigo, Spain.ORCID 0000-0002-3474-2139
Lluis TortDepartment of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, 08193 Barcelona, Spain.
Sebastián BoltanaCentro de Biotecnología, Departamento de Oceanografía, Universidad de Concepción, Concepción 4030000, Chile.ORCID 0000-0002-5195-0490
University of Concepción · CLUniversidade de Vigo · ESUniversidad Mayor · CLUniversitat Autònoma de Barcelona · ES

Funding

Comisión Nacional de Investigación Científica y Tecnológica CONICYT-PCHA/National PhD 2018 grant 21181886Comisión Nacional de Investigación Científica y Tecnológica CONICYT-PCHA/National PhD grant 21181886Comisión Nacional de Investigación Científica y Tecnológica FONDECYT 1190627
6 · The paper itself

Abstract

The feeding behavior in fish is a complex activity that relies on the ability of the brain to integrate multiple signals to produce appropriate responses in terms of food intake, energy expenditure, and metabolic activity. Upon stress cues including viral infection or mediators such as the proinflammatory cytokines, prostaglandins, and cortisol, both Pomc and Npy/Agrp neurons from the hypothalamus are stimulated, thus triggering a response that controls both energy storage and expenditure. However, how appetite modulators or neuro-immune cues link pathogenesis and energy homeostasis in fish remains poorly understood. Here, we provide the first evidence of a molecular linkage between inflammation and food intake in

Indexed as

Birnaviridae InfectionsFeeding BehaviorInflammationLipid MetabolismAnimalsCytokinesHypothalamusInfectious pancreatic necrosis virusInsulinLeptinSalmo salarSignal TransductionCytokinesInsulinLeptinfeeding behaviorinfectioninflammationlipid metabolism

Identifiers

PMID34768822
PMCPMC8583931
OpenAlexW3205593206

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.