Evidence map›Paper›PMID 34768917›Full record

ArticleInternational journal of molecular sciences2021

Rejuvenating the Aging Heart by Enhancing the Expression of the

Chi-Hsiao Yeh, Yi-Ju Chou, Ting-Kuan Chu, Ting-Fen Tsai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Cellular and molecular mechanisms underlying cardiovascular aging.Cellular & molecular biology letters · 2025
    Review
  2. Hesperetin Alleviates Bleomycin-Induced Pulmonary Fibrosis by Modulating Cellular Senescence and Promoting Impaired Autophagy in a CISD2-Dependent Manner.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  3. Metabolic Changes in Cardiac Aging.Reviews in cardiovascular medicine · 2023
    Review
  4. Rejuvenation: Turning Back Time by Enhancing CISD2.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Chi-Hsiao YehCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0002-8850-4144
Yi-Ju ChouInstitute of Molecular and Genomic Medicine, National Health Research Institute, Zhunan, Miaoli 350, Taiwan.
Ting-Kuan ChuDepartment of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Ting-Fen TsaiInstitute of Molecular and Genomic Medicine, National Health Research Institute, Zhunan, Miaoli 350, Taiwan.
National Yang Ming Chiao Tung University · TWChang Gung University · TWNational Health Research Institutes · TW

Funding

Chang Gung Memorial Hospital CMRPG3K2241Chang Gung Memorial Hospital CORPG2H0041-0043Ministry of Science and Technology MOST 109-2320-B-010-043Ministry of Science and Technology MOST109-2320-B-182A-020Ministry of Science and Technology MOST 109-2634-F-010-003Ministry of Science and Technology MOST110-2314-B-182A-113-MY3
6 · The paper itself

Abstract

Aging is the major risk factor for cardiovascular disease, which is the leading cause of mortality worldwide among aging populations.

Indexed as

AgingAnimalsAutophagyAutophagy-Related ProteinsCellular SenescenceEndomyocardial FibrosisHeartLongevityMiceMice, Inbred C57BLMice, TransgenicNerve Tissue ProteinsRejuvenationSirtuinsTranscriptomeAutophagy-Related ProteinsNerve Tissue ProteinsNoxp70 protein, mouseSirtuinscardiac agingcardiac rejuvenationCisd2inducible cardiac-specific overexpression

Identifiers

PMID34768917
PMCPMC8583758
OpenAlexW3208249485

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.