Evidence map›Paper›PMID 34769027›Full record

ArticleInternational journal of molecular sciences2021

Diazoxide Needs Mitochondrial Connexin43 to Exert Its Cytoprotective Effect in a Cellular Model of CoCl

Michela Pecoraro, Stefania Marzocco, Ada Popolo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michela PecoraroDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
Stefania MarzoccoDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0003-2333-1630
Ada PopoloDepartment of Pharmacy, University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0002-9843-8443
University of Salerno · IT

Funding

University of Salerno FARB 2020-ORSA 208878 and FARB 2020-ORSA209458
6 · The paper itself

Abstract

Hypoxia is the leading cause of death in cardiomyocytes. Cells respond to oxygen deprivation by activating cytoprotective programs, such as mitochondrial connexin43 (mCx43) overexpression and the opening of mitochondrial K

Indexed as

AnimalsApoptosisCell LineCell SurvivalCobaltConnexin 43CytoprotectionDiazoxideHypoxiaMembrane Potential, MitochondrialMitochondria, HeartMyocytes, CardiacPotassium ChannelsRatsReactive Oxygen SpeciesCobaltcobaltous chlorideConnexin 43DiazoxideGja1 protein, ratmitochondrial K(ATP) channelPotassium ChannelsReactive Oxygen Specieschemical hypoxiadiazoxideKATP channelsmCx43

Identifiers

PMID34769027
PMCPMC8583808
OpenAlexW3208908613

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.