Evidence map›Paper›PMID 34769115›Full record

ArticleInternational journal of molecular sciences2021

Chronic Activation of AMPK Induces Mitochondrial Biogenesis through Differential Phosphorylation and Abundance of Mitochondrial Proteins in

Malgorzata Heidorn-Czarna, Herbert-Michael Heidorn, Sanjanie Fernando, Oana Sanislav, Wieslawa Jarmuszkiewicz, Rupert Mutzel, Paul R Fisher

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Complex II Biology in Aging, Health, and Disease.Antioxidants (Basel, Switzerland) · 2023
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Malgorzata Heidorn-CzarnaDepartment of Biology, Chemistry, Pharmacy, Institute for Biology-Microbiology, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0000-0003-0850-2681
Herbert-Michael HeidornDepartment of Biology, Chemistry, Pharmacy, Institute for Biology-Microbiology, Freie Universität Berlin, 14195 Berlin, Germany.
Sanjanie FernandoDiscipline of Microbiology, Department of Physiology, Anatomy and Microbiology, School of Life Sciences, College of Science, Health and Engineering, La Trobe University, Bundoora, VIC 3086, Australia.
Oana SanislavDiscipline of Microbiology, Department of Physiology, Anatomy and Microbiology, School of Life Sciences, College of Science, Health and Engineering, La Trobe University, Bundoora, VIC 3086, Australia.ORCID 0000-0001-8550-8337
Wieslawa JarmuszkiewiczLaboratory of Mitochondrial Biochemistry, Department of Bioenergetics, Faculty of Biology, Adam Mickiewicz University, 61-614 Poznan, Poland.
Rupert MutzelDepartment of Biology, Chemistry, Pharmacy, Institute for Biology-Microbiology, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0000-0003-1884-6306
Paul R FisherDiscipline of Microbiology, Department of Physiology, Anatomy and Microbiology, School of Life Sciences, College of Science, Health and Engineering, La Trobe University, Bundoora, VIC 3086, Australia.
La Trobe University · AUFreie Universität Berlin · DEAdam Mickiewicz University in Poznań · PLUniversity of Wrocław · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial biogenesis is a highly controlled process that depends on diverse signalling pathways responding to cellular and environmental signals. AMP-activated protein kinase (AMPK) is a critical metabolic enzyme that acts at a central control point in cellular energy homeostasis. Numerous studies have revealed the crucial roles of AMPK in the regulation of mitochondrial biogenesis; however, molecular mechanisms underlying this process are still largely unknown. Previously, we have shown that, in cellular slime mould

Indexed as

Organelle BiogenesisAMP-Activated Protein KinasesDictyosteliumEnzyme ActivationMitochondrial ProteinsPhosphorylationAMP-Activated Protein KinasesMitochondrial ProteinsAMP-activated protein kinaseAMPKDictyostelium discoideummitochondrial biogenesismitochondrial phosphoproteomemTORC1phosphoproteomics

Identifiers

PMID34769115
PMCPMC8584165
OpenAlexW3208827248

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.