ReviewInternational journal of molecular sciences2021
The Entorhinal Cortex and Adult Neurogenesis in Major Depression.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Disrupted intrathalamic and thalamocortical structural covariance networks in posttraumatic stress disorder.Network neuroscience (Cambridge, Mass.) · 2026Article
- Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group.Molecular psychiatry · 2025Article
- Olfactory Dysfunction and Cognitive Decline: Are They Related?Current allergy and asthma reports · 2025Review
- Mechanisms of Baishao () and Gancao () on major depressive disorder: network pharmacology and o validation.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Seahorse Attenuated DSS-Induced Depression in Mice by Inhibiting Neuroinflammation and Ferroptosis.Food science & nutrition · 2025Article
- Quantity and Quality Matter: Different Neuroanatomical Substrates of Apathy in Alzheimer's Disease and Behavioural Variant Frontotemporal Dementia.Brain sciences · 2025Article
- Gut proinflammatory bacteria is associated with abnormal functional connectivity of hippocampus in unmedicated patients with major depressive disorder.Translational psychiatry · 2024Article
- Mice Mutated in the First Fibronectin Domain of Adhesion Molecule L1 Show Brain Malformations and Behavioral Abnormalities.Biomolecules · 2024Article
- Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine.Translational psychiatry · 2024Article
- MiR-182-5p: A Novel Biomarker in the Treatment of Depression in CSDS-Induced Mice.The international journal of neuropsychopharmacology · 2024Article
- miR-204-5p Plays a Critical Role in the Pathogenesis of Depression and Anti-depression Action of Venlafaxine in the Hippocampus of Mice.Current medicinal chemistry · 2024Article
- Brain imaging derived phenotypes: a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complications.Frontiers in immunology · 2024Article
- Associations between blood leukocyte DNA methylation and sustained attention in mid-to-late childhood.Epigenomics · 2023Article
- Presenilin-1-Derived Circular RNAs: Neglected Epigenetic Regulators with Various Functions in Alzheimer's Disease.Biomolecules · 2023Article
- Brain organoids are new tool for drug screening of neurological diseases.Neural regeneration research · 2023Review
- Predictive modeling of optimism bias using gray matter cortical thickness.Scientific reports · 2023Article
- Lipids in major depressive disorder: new kids on the block or old friends revisited?Frontiers in psychiatry · 2023Review
- The pathobiological basis of depression in Parkinson disease: challenges and outlooks.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Single-cell analysis reveals transcriptomic reprogramming in aging primate entorhinal cortex and the relevance with Alzheimer's disease.Aging cell · 2022Article
- The Relationship between Stress, Inflammation, and Depression.Biomedicines · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is characterized by impairments in adult neurogenesis. Reduced hippocampal function, which is suggestive of neurogenesis impairments, is associated with depression-related phenotypes. As adult neurogenesis operates in an activity-dependent manner, disruption of hippocampal neurogenesis in depression may be a consequence of neural circuitry impairments. In particular, the entorhinal cortex is known to have a regulatory effect on the neural circuitry related to hippocampal function and adult neurogenesis. However, a comprehensive understanding of how disruption of the neural circuitry can lead to neurogenesis impairments in depression remains unclear with respect to the regulatory role of the entorhinal cortex. This review highlights recent findings suggesting neural circuitry-regulated neurogenesis, with a focus on the potential role of the entorhinal cortex in hippocampal neurogenesis in depression-related cognitive and emotional phenotypes. Taken together, these findings may provide a better understanding of the entorhinal cortex-regulated hippocampal neurogenesis model of depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.