Evidence map›Paper›PMID 34769204›Full record

ReviewInternational journal of molecular sciences2021

An Outlook on Global Regulatory Landscape for Genome-Edited Crops.

Aftab Ahmad, Nayla Munawar, Zulqurnain Khan, Alaa T Qusmani, Sultan Habibullah Khan, Amer Jamil, Sidra Ashraf, Muhammad Zubair Ghouri, Sabin Aslam, Muhammad Salman Mubarik and 4 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Review
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  5. Achieving High-Density and Stress-Resilient Maize Breeding Via Germplasm Innovation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  14. Macrophage-cancer cell crosstalk in breast cancer chemotherapy resistance.Medical oncology (Northwood, London, England) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aftab AhmadCenter for Advanced Studies in Agriculture and Food Security (CASAFS), University of Agriculture, Faisalabad 38000, Pakistan.
Nayla MunawarDepartment of Chemistry, United Arab Emirates University, Al-Ain 15551, United Arab Emirates.ORCID 0000-0001-9448-2845
Zulqurnain KhanInstitute of Plant Breeding and Biotechnology, MNS University of Agriculture Multan, Multan 60000, Pakistan.ORCID 0000-0002-6910-7389
Alaa T QusmaniBiology Department, Al-Jumum University College, Umm Al-Qura University, Makkah 24243, Saudi Arabia.
Sultan Habibullah KhanCenter for Advanced Studies in Agriculture and Food Security (CASAFS), University of Agriculture, Faisalabad 38000, Pakistan.
Amer JamilDepartment of Biochemistry, University of Agriculture, Faisalabad 38000, Pakistan.ORCID 0000-0003-4039-4166
Sidra AshrafDepartment of Biochemistry, University of Agriculture, Faisalabad 38000, Pakistan.
Muhammad Zubair GhouriCenter for Advanced Studies in Agriculture and Food Security (CASAFS), University of Agriculture, Faisalabad 38000, Pakistan.
Sabin AslamCenter for Advanced Studies in Agriculture and Food Security (CASAFS), University of Agriculture, Faisalabad 38000, Pakistan.
Muhammad Salman MubarikCenter for Advanced Studies in Agriculture and Food Security (CASAFS), University of Agriculture, Faisalabad 38000, Pakistan.ORCID 0000-0001-6522-4660
Ahmad MunirDepartment of Biochemistry, University of Agriculture, Faisalabad 38000, Pakistan.ORCID 0000-0002-1970-4206
Qaiser SultanCenter for Advanced Studies in Agriculture and Food Security (CASAFS), University of Agriculture, Faisalabad 38000, Pakistan.
Kamel A Abd-ElsalamPlant Pathology Research Institute, Agricultural Research Center (ARC), Giza 12619, Egypt.ORCID 0000-0002-4042-4022
Sameer H QariMolecular Biology Central Laboratory (GMCL), Department of Biology/Genetics, Aljumum University College, Umm Al-Qura University, Makkah 24243, Saudi Arabia.ORCID 0000-0001-9424-5217

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The revolutionary technology of CRISPR/Cas systems and their extraordinary potential to address fundamental questions in every field of biological sciences has led to their developers being awarded the 2020 Nobel Prize for Chemistry. In agriculture, CRISPR/Cas systems have accelerated the development of new crop varieties with improved traits-without the need for transgenes. However, the future of this technology depends on a clear and truly global regulatory framework being developed for these crops. Some CRISPR-edited crops are already on the market, and yet countries and regions are still divided over their legal status. CRISPR editing does not require transgenes, making CRISPR crops more socially acceptable than genetically modified crops, but there is vigorous debate over how to regulate these crops and what precautionary measures are required before they appear on the market. This article reviews intended outcomes and risks arising from the site-directed nuclease CRISPR systems used to improve agricultural crop plant genomes. It examines how various CRISPR system components, and potential concerns associated with CRISPR/Cas, may trigger regulatory oversight of CRISPR-edited crops. The article highlights differences and similarities between GMOs and CRISPR-edited crops, and discusses social and ethical concerns. It outlines the regulatory framework for GMO crops, which many countries also apply to CRISPR-edited crops, and the global regulatory landscape for CRISPR-edited crops. The article concludes with future prospects for CRISPR-edited crops and their products.

Indexed as

CRISPR-Cas SystemsGene EditingGenome, PlantPlant BreedingCrops, AgriculturalPlants, Genetically ModifiedTransgenesCRISPR/Cas 3CRISPR cropsgenome editing 2global regulations 4

Identifiers

PMID34769204
PMCPMC8583973

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.