Evidence map›Paper›PMID 34769279›Full record

ArticleInternational journal of molecular sciences2021

Cell Surface and Functional Features of Cortical Bone Stem Cells.

Norihiko Sasaki, Yoko Itakura, Sadia Mohsin, Tomoaki Ishigami, Hajime Kubo, Yumi Chiba

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Norihiko SasakiResearch Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan.
Yoko ItakuraResearch Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan.
Sadia MohsinCardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Medical Education and Research Building, 3500N. Broad St., Philadelphia, PA 19140, USA.ORCID 0000-0002-2106-1094
Tomoaki IshigamiSchool of Medicine, Medical Course, Medical Sciences and Cardiorenal Medicine, Yokohama City University, Yokohama 236-0004, Japan.
Hajime KuboCardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Medical Education and Research Building, 3500N. Broad St., Philadelphia, PA 19140, USA.
Yumi ChibaResearch Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan.
Tokyo Metropolitan Institute of Gerontology · JPTemple University · USYokohama City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The newly established mouse cortical-bone-derived stem cells (mCBSCs) are unique stem cells compared to mouse mesenchymal stem cells (mMSCs). The mCBSC-treated hearts after myocardial infarction have been reported to have greater improvement in myocardial structure and functions. In this study, we examined the stemness features, cell surface glycan profiles, and paracrine functions of mCBSCs compared with mMSCs. The stemness analysis revealed that the self-renewing capacity of mCBSCs was greater than mMSCs; however, the differentiation capacity of mCBSCs was limited to the chondrogenic lineage among three types of cells (adipocyte, osteoblast, chondrocyte). The cell surface glycan profiles by lectin array analysis revealed that α2-6sialic acid is expressed at very low levels on the cell surface of mCBSCs compared with that on mMSCs. In contrast, the lactosamine (Galβ1-4GlcNAc) structure, poly lactosamine- or poly

Indexed as

Cell DifferentiationAnimalsCortical BoneMaleMiceMice, TransgenicStem CellsTransforming Growth Factor beta1Tgfb1 protein, mouseTransforming Growth Factor beta1cortical bone stem cellsglycan profilestemnessTGF-β1

Identifiers

PMID34769279
PMCPMC8584423
OpenAlexW3167994666

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.