Evidence map›Paper›PMID 34769288›Full record

ReviewInternational journal of molecular sciences2021

Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis.

Peir-Haur Hung, Yung-Chien Hsu, Tsung-Hsien Chen, Chun-Liang Lin

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 3 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 3 syntheses or guidelines pooled it, 130 citations in OpenAlex.

  1. The efficacy and safety ofFrontiers in pharmacology · 2024
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  17. Multi-Omics Integration IdentifiesInternational journal of molecular sciences · 2025
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  18. Drynachromoside A fromRedox report : communications in free radical research · 2025
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Peir-Haur HungDepartment of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 600566, Taiwan.ORCID 0000-0002-5963-6981
Yung-Chien HsuDepartment of Nephrology, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.
Tsung-Hsien ChenDepartment of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 600566, Taiwan.ORCID 0000-0002-1542-1495
Chun-Liang LinDepartment of Nephrology, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.ORCID 0000-0002-5710-8405
Chia-Yi Christian Hospital · TWChang Gung University · TWChiayi Chang Gung Memorial Hospital · TW

Funding

Chang Gung Memorial Hospital at Chiayi, Taiwan CMRPG6F0381-3
6 · The paper itself

Abstract

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the detailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.

Indexed as

Gene Regulatory NetworksDiabetic NephropathiesGlomerular Filtration RateHumansKidney Failure, Chronicalbuminuriadiabetic kidney diseasefibrosisglomerulosclerosisinflammation

Identifiers

PMID34769288
PMCPMC8584225
OpenAlexW3210448505

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.