Evidence map›Paper›PMID 34769427›Full record

ArticleInternational journal of molecular sciences2021

Comparative Neuropharmacology and Pharmacokinetics of Methamphetamine and Its Thiophene Analog Methiopropamine in Rodents.

Silja Skogstad Tuv, Marianne Skov-Skov Bergh, Jannike Mørch Andersen, Synne Steinsland, Vigdis Vindenes, Michael H Baumann, Marilyn A Huestis, Inger Lise Bogen

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. New psychoactive substances: a multidisciplinary review of challenges and their diverse character.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2025
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Silja Skogstad TuvDepartment of Forensic Sciences, Oslo University Hospital, 0456 Oslo, Norway.
Marianne Skov-Skov BerghDepartment of Forensic Sciences, Oslo University Hospital, 0456 Oslo, Norway.
Jannike Mørch AndersenDepartment of Forensic Sciences, Oslo University Hospital, 0456 Oslo, Norway.
Synne SteinslandDepartment of Forensic Sciences, Oslo University Hospital, 0456 Oslo, Norway.
Vigdis VindenesDepartment of Forensic Sciences, Oslo University Hospital, 0456 Oslo, Norway.
Michael H BaumannDesigner Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA.
Marilyn A HuestisInstitute of Emerging Health Professions, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Inger Lise BogenDepartment of Forensic Sciences, Oslo University Hospital, 0456 Oslo, Norway.
Oslo University Hospital · NONational Institute on Drug Abuse · USThomas Jefferson University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methiopropamine is a novel psychoactive substance (NPS) that is associated with several cases of clinical toxicity, yet little information is available regarding its neuropharmacological properties. Here, we employed in vitro and in vivo methods to compare the pharmacokinetics and neurobiological effects of methiopropamine and its structural analog methamphetamine. Methiopropamine was rapidly distributed to the blood and brain after injection in C57BL/6 mice, with a pharmacokinetic profile similar to that of methamphetamine. Methiopropamine induced psychomotor activity, but higher doses were needed (E

Indexed as

AnimalsBrainCentral Nervous System StimulantsLocomotionMaleMethamphetamineMiceMice, Inbred C57BLNeuropharmacologyThiophenesTissue Distribution1-(2-thienyl)-2-(methylamino)propaneCentral Nervous System StimulantsMethamphetamineThiopheneslocomotor activitymethamphetaminemethiopropaminemouseneuropharmacologynovel psychoactive substanceNPSpharmacokineticspharmacologypsychostimulant

Identifiers

PMID34769427
PMCPMC8585037
OpenAlexW3214315518

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.