Evidence map›Paper›PMID 34769516›Full record

ArticleInternational journal of molecular sciences2021

Dual Role of Thrombospondin-1 in Flow-Induced Remodeling.

Céline Grenier, Antoine Caillon, Mathilde Munier, Linda Grimaud, Tristan Champin, Bertrand Toutain, Céline Fassot, Olivier Blanc-Brude, Laurent Loufrani

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Céline GrenierUMR CNRS 6015, 49100 Angers, France.ORCID 0000-0003-4521-9404
Antoine CaillonUMR CNRS 6015, 49100 Angers, France.
Mathilde MunierUMR CNRS 6015, 49100 Angers, France.
Linda GrimaudUMR CNRS 6015, 49100 Angers, France.
Tristan ChampinUMR CNRS 6015, 49100 Angers, France.
Bertrand ToutainUMR CNRS 6015, 49100 Angers, France.
Céline FassotUMR CNRS 6015, 49100 Angers, France.
Olivier Blanc-BrudeUMR Inserm 970 ParCC-Paris Cardiovascular Center HEGP, 75015 Paris, France.
Laurent LoufraniUMR CNRS 6015, 49100 Angers, France.ORCID 0000-0003-3397-2335
Centre National de la Recherche Scientifique · FRInserm · FR

Funding

Agence Nationale de la Recherche Vasc-TSP-1
6 · The paper itself

Abstract

(1) Background: Chronic increases in blood flow, as in cardiovascular diseases, induce outward arterial remodeling. Thrombospondin-1 (TSP-1) is known to interact with matrix proteins and immune cell-surface receptors, but its contribution to flow-mediated remodeling in the microcirculation remains unknown. (2) Methods: Mesenteric arteries were ligated in vivo to generate high- (HF) and normal-flow (NF) arteries in wild-type (WT) and TSP-1-deleted mice (TSP-1

Indexed as

AnimalsEndothelium, VascularMesenteric ArteriesMiceMice, KnockoutMicrocirculationModels, AnimalRegional Blood FlowThrombospondin 1VasodilationThbs1 protein, mouseThrombospondin 1blood flowimmune cellsremodelingresistance arteriesthrombospondin-1

Identifiers

PMID34769516
PMCPMC8584526
OpenAlexW3211805716

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.