Trial reportScientific reports2021
Correlation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: an open-label intervention trial.
Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Dietary Carbohydrates and ADHD Symptoms: A Systematic Review.Nutrients · 2026Pooled it
- Physical Complaints Decrease after Following a Few-Foods Diet in Children with ADHD.Nutrients · 2022Trial
- Microbiome signatures correlate with diet-mediated ADHD symptom reduction.Gut microbes · 2026Article
- Nutritional Influences on the Brain in ADHD: Evidence from Neuroimaging Studies.Neurology international · 2026Review
- [The microbiota-gut-brain axis in childhood attention-deficit/hyperactivity disorder: mechanisms and therapeutic advances].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Review
- Article
- Gut-Brain Inflammatory Pathways in Attention-Deficit/Hyperactivity Disorder: The Role and Therapeutic Potential of Diet.Metabolites · 2025Review
- The gut microbiota-immune-brain axis: Therapeutic implications.Cell reports. Medicine · 2025Review
- Magnetic resonance imaging evaluation and nuclear receptor binding SET domain protein 1 mutation in the Sotos syndrome with attention-deficit/hyperactivity disorder.World journal of clinical cases · 2025Article
- Microbiome: A Key Regulator of Body-Brain Interactions.Advances in experimental medicine and biology · 2025Review
- Investigating the Impact of Nutrition and Oxidative Stress on Attention Deficit Hyperactivity Disorder.Nutrients · 2024Review
- Role of LncMALAT1-miR-141-3p/200a-3p-NRXN1 Axis in the Impairment of Learning and Memory Capacity in ADHD.Physiological research · 2023Article
- Nutrition in the Management of ADHD: A Review of Recent Research.Current nutrition reports · 2023Review
- Diet and special educational needs (SENs) among children and adolescents: a systematic review.Porto biomedical journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Research into the effect of nutrition on attention-deficit hyperactivity disorder (ADHD) in children has shown that the few-foods diet (FFD) substantially decreases ADHD symptoms in 60% of children. However, the underlying mechanism is unknown. In this open-label nutritional intervention study we investigated whether behavioural changes after following an FFD are associated with changes in brain function during inhibitory control in 79 boys with ADHD, aged 8-10 years. Parents completed the ADHD Rating Scale before (t1) and after the FFD (t2). Functional magnetic resonance imaging (fMRI) scans were acquired during a stop-signal task at t1 and t2, and initial subject-level analyses were done blinded for ARS scores. Fifty (63%) participants were diet responders, showing a decrease of ADHD symptoms of at least 40%. Fifty-three children had fMRI scans of sufficient quality for further analysis. Region-of-interest analyses demonstrated that brain activation in regions implicated in the stop-signal task was not associated with ADHD symptom change. However, whole-brain analyses revealed a correlation between ADHD symptom decrease and increased precuneus activation (p
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.