Evidence map›Paper›PMID 34774980›Full record

ReviewNeuroscience letters2022

Epigenetic regulation in the neurogenic niche of the adult dentate gyrus.

Ryan N Sheehy, Luis J Quintanilla, Juan Song

Open access · greenAbstract readReview
In one paragraph

Review in Neuroscience letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. SETDB1 ensures the continuity of embryonic to adult neural stem cells through metabolic alterations in the dentate gyrus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ryan N SheehyDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Pharmacology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: rnsheehy@email.unc.edu.
Luis J QuintanillaDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Neuroscience Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Juan SongDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: juansong@email.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Predoctoral Training in the Pharmacological SciencesT32GM135095 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Mauro Calabrese, Michael James Emanuele · 2020 to 2026
$3.6M
Sex-dependent role of 5HT1A receptors in adult neurogenesis and hippocampal functionR01MH122692 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2020 to 2024
$2.9M
Role of Cholecystokinin in the Dentate GyrusR01NS121300 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2021 to 2025
$2.3M
Neural circuitry mechanisms regulating adult hippocampal neurogenesisR01MH111773 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2016 to 2020
$2.0M
Glutamatergic neural circuit modulation for treating Alzheimer’s diseaseRF1AG071000 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2021 to 2021
$1.9M
The role of the septo-hippocampal cholinergic circuit in regulating hippocampal functionF31AG067718 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI QUINTANILLA, LUIS · 2020 to 2021
$68k
NIA NIH HHS F31 AG067718NIA NIH HHS RF1 AG071000NIGMS NIH HHS T32 GM135095NIMH NIH HHS R01 MH111773NIMH NIH HHS R01 MH122692NINDS NIH HHS R01 NS121300
6 · The paper itself

Abstract

The adult dentate gyrus (DG) of the hippocampal formation is a specialized region of the brain that creates new adult-born neurons from a pool of resident adult neural stem and progenitor cells (aNSPCs) throughout life. These aNSPCs undergo epigenetic and epitranscriptomic regulation, including 3D genome interactions, histone modifications, DNA modifications, noncoding RNA mechanisms, and RNA modifications, to precisely control the neurogenic process. Furthermore, the specialized neurogenic niche also uses epigenetic mechanisms in mature neurons and glial cells to communicate signals to direct the behavior of the aNSPCs. Here, we review recent advances of epigenetic regulation in aNSPCs and their surrounding niche cells within the adult DG.

Indexed as

Adult Stem CellsDentate GyrusEpigenesis, GeneticNeural Stem CellsNeurogenesisStem Cell NicheAnimalsHumansAdult neurogenesisDentate gyrusEpigeneticsEpitranscriptomicsHippocampusLearning and memoryNeural stem cells

Identifiers

PMID34774980
PMCPMC8691367
OpenAlexW3211607018

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.