ArticleBiological psychiatry2022
Racial Discrimination and White Matter Microstructure in Trauma-Exposed Black Women.
Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 45 citations in OpenAlex.
- Racism and alterations in brain structure and function: A narrative review of emerging neuroimaging evidence in racialized individuals.Cognitive, affective & behavioral neuroscience · 2026Review
- Racialized Heteroscedasticity in Neuroimaging Features, Behavior Measures, and Neuroimaging-Based Predictive Models.Research square · 2026Article
- Do white matter hyperintensities account for the relationship between discrimination and memory?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Associations between amygdala connectivity and experienced discrimination in children.bioRxiv : the preprint server for biology · 2026Article
- Neural reactivity to a racial trauma cue in an African American woman with alcohol use disorder and PTSD: Case report.Psychiatry research case reports · 2025Article
- The relationship between racial discrimination and white matter among Black older adults.Neurobiology of aging · 2025Article
- Identifying neural mediators and cultural moderators of the association between discrimination and depression among Mexican American youth.Scientific reports · 2025Article
- Environmental Adversity Is Associated With Attenuated Positive Symptoms and Complex Cognition in a Long-term Follow-up of the Philadelphia Neurodevelopmental Cohort.Schizophrenia bulletin · 2025Article
- Racial discrimination and anxiety in African American youth: Risk, resilience, and intervention.Journal of mood and anxiety disorders · 2025Review
- Fractional Anisotropy of Cingulum Cingulate Mediates the Relationship Between Happiness and Work Performance in Healthy Individuals.Brain and behavior · 2025Article
- Understanding Cognitive Aging Through White Matter: A Fixel-Based Analysis.Human brain mapping · 2024Article
- White matter correlates of dissociation in a diverse sample of trauma-exposed women.Psychiatry research · 2024Article
- Racial and ethnic socioenvironmental inequity and neuroimaging in psychiatry: a brief review of the past and recommendations for the future.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Population-level normative models reveal race- and socioeconomic-related variability in cortical thickness of threat neurocircuitry.Communications biology · 2024Article
- Sex, racial, andbioRxiv : the preprint server for biology · 2024Article
- Racial Discrimination, Neural Connectivity, and Epigenetic Aging Among Black Women.JAMA network open · 2024Article
- The neurophysiological consequences of racism-related stressors in Black Americans.Neuroscience and biobehavioral reviews · 2024Review
- Pathways explaining racial/ethnic and socio-economic disparities in brain white matter integrity outcomes in the UK Biobank study.SSM - population health · 2024Article
- Beyond gender: The biological impacts of inequality through the lens of intersectionality.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Personal Mastery Attenuates the Association between Greater Perceived Discrimination and Lower Amygdala and Anterior Hippocampal Volume in a Diverse Sample of Older Adults.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundExperiences of racial discrimination are linked to a range of negative brain health outcomes, but little is known about how these experiences impact neural architecture, including white matter microstructure, which may partially mediate these outcomes. Our goal was to examine associations between racially discriminatory experiences and white matter structural integrity in a sample of Black American women.
methodsWe recruited 116 Black American women as part of a long-standing study of trauma. Participants completed assessments of racial discrimination, trauma exposure, and posttraumatic stress disorder and underwent diffusion tensor imaging. Fractional anisotropy and mean diffusivity values were extracted from major white matter tracts throughout the brain.
resultsExperiences of racial discrimination were associated with significantly lower fractional anisotropy in multiple white matter tracts, including the corpus callosum, cingulum, and superior longitudinal fasciculus (ps < .004), even after accounting for variance associated with trauma, posttraumatic stress disorder, and demographic- and scanner-related factors.
conclusionsThese findings suggest that experiences of racial discrimination are independently related to decrements in white matter microarchitecture throughout the brain. In individuals who have experienced other types of adversity, racial discrimination clearly has additive and distinctive deleterious effects on white matter structure. Our findings suggest a pathway through which racial discrimination can contribute to brain health disparities in Black Americans; the deleterious contributions of racial discrimination on the microstructure of major white matter pathways may increase vulnerability for the development of neurodegenerative disorders as well as the development of mental health problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.