Evidence map›Paper›PMID 34778467›Full record

ReviewJournal of immunology research2021

Research Progress on the Mechanism of Natural Product Ingredients in the Treatment of Uveitis.

Sicong Li, Fang Liu, Kai Zhang, Yujia Tong, Xin Liu

Open access · goldAbstract readReview
In one paragraph

Review in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. A comprehensive review ofFrontiers in pharmacology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Sicong LiSchool of Pharmacy, Peking University Health Science Centre, Beijing, China.
Fang LiuDepartment of Pharmacy, China-Japan Friendship Hospital, Beijing, China.
Kai ZhangDepartment of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Yujia TongInstitute of Medical Information, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.
Xin LiuSchool of Traditional Chinese Medicine, Beijing University of Traditional Chinese Medicine, Beijing 100029, China.ORCID https://orcid.org/0000-0003-3593-3460
Peking University · CNBeijing Hospital of Traditional Chinese Medicine · CNChina-Japan Friendship Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs the spectrum of ophthalmic diseases keeps changing, uveitis has gradually become one of the major blinding eye diseases in the world. In recent years, it has become a research hotspot to select effective components for uveitis treatment from natural drugs.

methodsWe searched PubMed and EMBASE databases for studies written in English as well as Chinese National Knowledge Infrastructure (CNKI), CQVIP, and Wan Fang database for studies written in Chinese (inception through 30 December 2020).

resultsEight kinds of natural product ingredients were included in this article. They were found to not only regulate the expression of cytokines, proliferation, and differentiation of T help cells but also inhibit the damage of cytokines and inflammatory cells to uvea, blood aqueous barrier, and blood retinal barrier.

conclusionNatural product ingredients have their unique advantages in the treatment of uveitis. They have good anti-inflammatory effects without causing serious adverse reactions, which enables them to be promising choices for preventive and therapeutic strategy of uveitis.

Indexed as

AnimalsBiological ProductsCell DifferentiationCell ProliferationCytokinesDrugs, Chinese HerbalHumansT Follicular Helper CellsUveitisBiological ProductsCytokinesDrugs, Chinese Herbal

Identifiers

PMID34778467
PMCPMC8585548
OpenAlexW3184024256

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.