ReviewPhysiology (Bethesda, Md.)2022
Is It Good to Have a Stiff Aorta with Aging? Causes and Consequences.
Review in Physiology (Bethesda, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Effects of excess sodium consumption on arterial function in C57BL/6 mice.American journal of physiology. Heart and circulatory physiology · 2024Pooled it
- Effect of glycocalyx-targeted therapy on vascular function in older adults: a randomized controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Trial
- Calcific Aortopathy in Response to Aging and Injury.Circulation · 2026Review
- Mortality trends and disparities associated with aortic aneurysm and aortic dissection in the United States from 1999 to 2023: a CDC WONDER database analysis.BMC cardiovascular disorders · 2026Article
- Late-Onset Menopause Attenuates Aortic Stiffness in the Postmenopausal Period.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Associations of clinical obesity with arterial stiffness and cerebral small vessel disease: a population-based study.Frontiers in endocrinology · 2026Article
- Age-stratified analysis of descending aorta diameter in traumatic massive hemorrhage: a machine learning approach.Trauma surgery & acute care open · 2026Article
- Age-related hearing loss in healthy older adults is associated with arterial stiffening and higher aortic systolic blood pressure: potential role of inflammation.Frontiers in aging · 2026Article
- Association of estimated pulse wave velocity with asthma risk in middle-aged and older adults in China: a national cohort study.BMC public health · 2025Article
- Decreased Visibility of Deep Medullary Vein Associated with Cerebral Small Vessel Disease Burden through Increased Interstitial Fluid in White Matter.AJNR. American journal of neuroradiology · 2025Article
- Gonadal status modulates large elastic artery stiffness in healthy middle-aged and older men.GeroScience · 2025Article
- TcMAC21 mouse model recapitulates abnormal vascular physiology observed in humans with Down syndrome.Physiological reports · 2025Article
- Impact of Simulated Vascular Aging and Heart Rate on Myocardial Efficiency: A Tale of Two Paradigms from In Silico Modelling.Journal of cardiovascular development and disease · 2025Article
- The association between estimated pulse wave velocity and cardio-cerebrovascular disease risk: a cohort study.European journal of medical research · 2025Article
- Fracture properties of porcine versus human thoracic aortas from tricuspid/bicuspid aortic valve patients via symmetry-constraint Compact Tension testing.Scientific reports · 2025Article
- Association of aortic diameters and mortality in the general population-an MRI-based study.European radiology · 2025Article
- Load-dependent mechanisms contribute to increased aortic stiffness among women with a history of preeclampsia: relation with cardiovagal baroreflex sensitivity.American journal of physiology. Heart and circulatory physiology · 2024Article
- Lower estimates of myocardial perfusion are associated with greater aortic perivascular adipose tissue density in humans independent of aortic stiffness.American journal of physiology. Heart and circulatory physiology · 2024Article
- Comprehensive analysis of gene signatures associated with aging in human aortic dissection.Heliyon · 2024Article
- Exercise to Prevent Accelerated Vascular Aging in People Living With HIV.Circulation research · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Aortic stiffness increases with advancing age, more than doubling during the human life span, and is a robust predictor of cardiovascular disease (CVD) clinical events independent of traditional risk factors. The aorta increases in diameter and length to accommodate growing body size and cardiac output in youth, but in middle and older age the aorta continues to remodel to a larger diameter, thinning the pool of permanent elastin fibers, increasing intramural wall stress and resulting in the transfer of load bearing onto stiffer collagen fibers. Whereas aortic stiffening in early middle age may be a compensatory mechanism to normalize intramural wall stress and therefore theoretically "good" early in the life span, the negative clinical consequences of accelerated aortic stiffening beyond middle age far outweigh any earlier physiological benefit. Indeed, aortic stiffness and the loss of the "windkessel effect" with advancing age result in elevated pulsatile pressure and flow in downstream microvasculature that is associated with subclinical damage to high-flow, low-resistance organs such as brain, kidney, retina, and heart. The mechanisms of aortic stiffness include alterations in extracellular matrix proteins (collagen deposition, elastin fragmentation), increased arterial tone (oxidative stress and inflammation-related reduced vasodilators and augmented vasoconstrictors; enhanced sympathetic activity), arterial calcification, vascular smooth muscle cell stiffness, and extracellular matrix glycosaminoglycans. Given the rapidly aging population of the United States, aortic stiffening will likely contribute to substantial CVD burden over the next 2-3 decades unless new therapeutic targets and interventions are identified to prevent the potential avalanche of clinical sequelae related to age-related aortic stiffness.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.