Evidence map›Paper›PMID 34780524›Full record

ArticlePloS one2021

Serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression.

Hyun Seung Yang, Young Je Choi, Hee Yong Han, Hak Su Kim, So Hyun Park, Kyung Sub Lee, Sang Hwa Lim, Doo Jin Heo, Sangkyung Choi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hyun Seung YangGraduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.
Young Je ChoiDepartment of Ophthalmology, Veterans Health Service Medical Center, Seoul, South Korea.
Hee Yong HanDepartment of Ophthalmology, Veterans Health Service Medical Center, Seoul, South Korea.
Hak Su KimVeterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, South Korea.
So Hyun ParkDepartment of Endocrinology, Seoul Chuk Hospital, Eui Jung Bu, Gyeonggi-do, South Korea.
Kyung Sub LeeDepartment of Ophthalmology, Seoul Shinsegae Eye Center, Eui Jung Bu, Gyeonggi-do, South Korea.
Sang Hwa LimDepartment of Ophthalmology, Seoul Shinsegae Eye Center, Eui Jung Bu, Gyeonggi-do, South Korea.
Doo Jin HeoDepartment of Ophthalmology, Seoul Shinsegae Eye Center, Eui Jung Bu, Gyeonggi-do, South Korea.
Sangkyung ChoiDepartment of Ophthalmology, Veterans Health Service Medical Center, Seoul, South Korea.ORCID 0000-0002-0973-1104
Veterans Health Service Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare adiponectin (APN) levels in the serum and aqueous humor (AH) and evaluate their association with the development/progression of diabetic retinopathy (DR).

methodsDiabetic patients with (group 3; n = 59) and without (group 2; n = 39) DR and age- and sex-matched normal subjects (group 1; n = 35) were compared. Duration of diabetes, body mass index, serum HbA1c, vascular endothelial growth factor (VEGF), APN, pentraxin 3 (PTX3), platelet derived growth factor (PDGF), intercellular adhesion molecule-1 (ICAM-1), and APN were measured and analyzed.

resultsOne hundred and thirty-three participants were included. Compared to patients without diabetes, diabetic patients with DR had significantly elevated average serum APN levels (5.99±3.89 μg/ml versus 3.51±1.44 μg/ml, P = 0.002) and average AH APN levels (10.94±11.74 ng/ml versus 3.65±3.33 ng/ml, P<0.001). Serum APN was significantly correlated with AH APN (R = 0.512, P<0.001) and AH VEGF (R = 0.202, P = 0.020). The log serum APN was significantly correlated with intraocular cytokines, including log APN, log VEGF, log ICAM, log leptin, log PTX3, log PDGF, angiopoietin, C-reactive protein, and interleukins (IL)-5 and IL-10 (P<0.001, P = 0.020, P<0.001, P<0.001, P = 0.001, P<0.001, P = 0.008, P = 0.009, P<0.001, and P = 0.046, respectively). Log serum VEGF showed a significant correlation only with log AH VEGF (P = 0.001). Multivariate logistic analysis was performed to evaluate the association of DR progression and cytokine concentrations; log Serum APN and log AH APN showed good correlation with the DR progression in each model.

conclusionsAH APN levels correlated well with DR development and progression. Serum APN could be a better marker for estimating intraocular cytokines, including both intraocular APN and VEGF concentrations in clinical field, than serum VEGF in DR patients.

Indexed as

AdiponectinAgedAged, 80 and overAqueous HumorC-Reactive ProteinDiabetic RetinopathyFemaleHumansIntercellular Adhesion Molecule-1MalePentraxinsPlatelet-Derived Growth FactorSerum Amyloid P-ComponentVascular Endothelial Growth Factor AAdiponectinC-Reactive ProteinICAM1 protein, humanIntercellular Adhesion Molecule-1PentraxinsPlatelet-Derived Growth FactorSerum Amyloid P-ComponentVascular Endothelial Growth Factor A

Identifiers

PMID34780524
PMCPMC8592425
OpenAlexW3211915944

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.