SynthesisCritical care (London, England)2021
Prediction of extubation outcome in critically ill patients: a systematic review and meta-analysis.
Synthesis in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Ventilation-Weaning Protocols in Children Admitted to Pediatric Intensive Care Units: Systematic Review of Randomized Trials.Pediatric pulmonology · 2025Pooled it
- Handgrip strength association with weaning outcome in mechanically ventilated ICU patients: a systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Comparison of Postextubation Complications Between Positive-Pressure and Suctioning Techniques: A Systematic Review.Respiratory care · 2023Pooled it
- Effect of the extubation predictive score (ExPreS) on reintubation in the ICU: a randomized controlled trial.Critical care (London, England) · 2026Trial
- Comparison of positive pressure extubation with traditional extubation in critically ill patients - a randomised control study.Anaesthesiology intensive therapy · 2023Trial
- Trial
- Liberation from Mechanical Ventilation in Acute Hypoxemic Respiratory Failure or Adult Respiratory Distress Syndrome: A Review.Journal of clinical medicine · 2026Review
- A temporal deep learning algorithm for prediction of extubation failures in critical care patients.Journal of clinical monitoring and computing · 2026Article
- Machine learning models predicting extubation success in mechanically ventilated patients: a systematic review and meta-analysis.Intensive care medicine experimental · 2026Review
- Perioperative use of eculizumab in patients with thymoma-associated myasthenia gravis: A preliminary case series of five patients.IBRO neuroscience reports · 2026Article
- Mechanical ventilation for ICU patient with obesity: current best practices and future directions.Intensive care medicine · 2026Review
- Association of extubation failure rate with patient outcomes.Acute and critical care · 2026Article
- Extubation Decision Support in Critical Care: A Multimodal Machine Learning Framework Integrating Segmented Radiographs and Routine Clinical Data.Journal of imaging informatics in medicine · 2026Article
- Explainable machine learning prediction of tracheostomy after craniotomy for supratentorial intracerebral hemorrhage.Scientific reports · 2026Article
- Machine learning-driven prediction model for successful weaning of patients from mechanical ventilation in ICU.Intensive care medicine experimental · 2026Article
- Nursing Management of Repeated Extubation Failure Following Colonic Volvulus Surgery in a Patient with Alstrom Syndrome: A Case Report.Journal of inflammation research · 2026Article
- Article
- Predicting failure of extubation and non-invasive respiratory support in critically ill patients: clinical complexity, limitations of traditional indices, and machine learning perspectives.Frontiers in medicine · 2026Review
- Construction and validation of a machine learning-based prediction model for 48-hour reintubation risk in mechanically ventilated patients.Frontiers in medicine · 2026Article
- "One-way" clinical extubation: an alternative to tracheostomy or palliative extubation in patients receiving inappropriate mechanical ventilation?Critical care science · 2026Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtubation failure is an important issue in ventilated patients and its risk factors remain a matter of research. We conducted a systematic review and meta-analysis to explore factors associated with extubation failure in ventilated patients who passed a spontaneous breathing trial and underwent planned extubation. This systematic review was registered in PROPERO with the Registration ID CRD42019137003.
methodsWe searched the PubMed, Web of Science and Cochrane Controlled Register of Trials for studies published from January 1998 to December 2018. We included observational studies involving risk factors associated with extubation failure in adult intensive care unit patients who underwent invasive mechanical ventilation. Two authors independently extracted data and assessed the validity of included studies.
resultsSixty-seven studies (involving 26,847 participants) met the inclusion criteria and were included in our meta-analysis. We analyzed 49 variables and, among them, we identified 26 factors significantly associated with extubation failure. Risk factors were distributed into three domains (comorbidities, acute disease severity and characteristics at time of extubation) involving mainly three functions (circulatory, respiratory and neurological). Among these, the physiological respiratory characteristics at time of extubation were the most represented. The individual topic of secretion management was the one with the largest number of variables. By Bayesian multivariable meta-analysis, twelve factors were significantly associated with extubation failure: age, history of cardiac disease, history of respiratory disease, Simplified Acute Physiologic Score II score, pneumonia, duration of mechanical ventilation, heart rate, Rapid Shallow Breathing Index, negative inspiratory force, lower PaO
conclusionsNumerous factors are associated with extubation failure in critically ill patients who have passed a spontaneous breathing trial. Robust multiparametric clinical scores and/or artificial intelligence algorithms should be tested based on the selected independent variables in order to improve the prediction of extubation outcome in the clinical scenario.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.