Evidence mapPaperPMID 34784231Full record

ArticleCirculation. Cardiovascular quality and outcomes2021

Echocardiographic and Electrocardiographic Abnormalities Among Elderly Adults With Cardiovascular Disease in Rural South Africa.

Enrico G Ferro, Shafika Abrahams-Gessel, Thiago Veiga Jardim, Ryan Wagner, F Xavier Gomez-Olive, Alisha N Wade, Ferande Peters, Stephen Tollman, Thomas A Gaziano

Open access · bronzeAbstract read
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 5 countries.

Enrico G FerroHarvard Medical School, Boston, MA (E.G.F.).
Shafika Abrahams-GesselCenter for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA (S.A.-G., T.V.J., T.A.G.).ORCID 0000-0003-4954-057X
Thiago Veiga JardimCenter for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA (S.A.-G., T.V.J., T.A.G.).ORCID 0000-0002-7750-2792
Ryan WagnerMedical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences (R.W., F.X.G.-O., A.N.W., S.T., T.A.G.), University of the Witwatersrand, Parktown, South Africa.ORCID 0000-0003-2741-3676
F Xavier Gomez-OliveMedical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences (R.W., F.X.G.-O., A.N.W., S.T., T.A.G.), University of the Witwatersrand, Parktown, South Africa.ORCID 0000-0002-4876-0848
Alisha N WadeMedical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences (R.W., F.X.G.-O., A.N.W., S.T., T.A.G.), University of the Witwatersrand, Parktown, South Africa.ORCID 0000-0002-1158-2523
Ferande PetersCardiovascular Pathophysiology and Genomics Unit (F.P.), University of the Witwatersrand, Parktown, South Africa.
Stephen TollmanMedical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences (R.W., F.X.G.-O., A.N.W., S.T., T.A.G.), University of the Witwatersrand, Parktown, South Africa.ORCID 0000-0003-0744-7588
Thomas A GazianoDepartment of Cardiovascular Medicine (T.A.G.), Brigham & Women's Hospital, Boston, MA.ORCID 0000-0002-5985-345X
University of the Witwatersrand · ZABrigham and Women's Hospital · USHarvard University · US

Funding

Project 4 - HAALSI NationalP01AG041710 · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2025 to 2025
$6.2M
Shared Core: Biobanking, Bioinformatics and Data ManagementU54HG006938 · NHGRI · WITS HEALTH CONSORTIUM (PTY), LTD · PI Michele Michele Ramsay · 2022 to 2022
$4.7M
FIC NIH HHS K43 TW010698NHGRI NIH HHS U54 HG006938NIA NIH HHS P01 AG041710Wellcome TrustWellcome Trust 058893/Z/99/AWellcome Trust 069683/Z/02/ZWellcome Trust 085477/B/08/ZWellcome Trust 085477/Z/08/Z
6 · The paper itself

Abstract

backgroundSub-Saharan Africa is undergoing an epidemiological transition fueled by the interaction between infectious and cardiovascular diseases. Our cross-sectional study aimed to characterize the spectrum of abnormalities suggesting end-organ damage on ECG and transthoracic echocardiograms (TTE) among older adults with cardiovascular diseases in rural South Africa.

methodsThe prevalence of ECG and TTE abnormalities was estimated; χ

resultsOverall, 729 ECGs and 155 TTEs were completed, with 74 participants completing both. ECG evaluation showed high rates of left ventricular hypertrophy (LVH, 36.5%) and T wave abnormalities (13.6%). TTE evaluation showed high rates of concentric LVH (31.6%), with moderate-severe (56.8%) diastolic dysfunction. Participants with hypertension showed more cardiac remodeling on ECG by LVH (45.4% versus 22.1%,

conclusionsOur findings suggest that cardiovascular diseases are widespread in rural South Africa, with a larger burden of hypertensive heart disease than previously appreciated, and define the severity of end-organ damage that is already underway. Local health systems must adapt to face the growing burden of hypertension, as suboptimal rates of hypertension diagnosis and treatment may dramatically increase the heart failure burden.

Indexed as

Cardiovascular DiseasesHypertensionAgedCross-Sectional StudiesEchocardiographyElectrocardiographyFemaleHumansHypertrophy, Left VentricularMaleSouth Africaagingcardiovascular diseasesechocardiographyhypertensionSouth Africa

Identifiers

PMID34784231
PMCPMC8627257
OpenAlexW3211557952

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.