Evidence map›Paper›PMID 34786049›Full record

ArticleAmerican journal of translational research2021

Pathologic role of peptidyl-prolyl isomerase Pin1 in pulmonary artery remodeling.

Caixia Wu, Yanping Ha, Yuan Zou, Xiaomin Liao, Shuya Zhang, Xiaodian Zhang, Rujia Li, Jingci Xing, Wei Jie, Junli Guo and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Caixia WuDepartment of Pathology & Pathophysiology, School of Basic Medicine Sciences, Guangdong Medical University Zhanjiang 524023, Guangdong, China.
Yanping HaDepartment of Pathology & Pathophysiology, School of Basic Medicine Sciences, Guangdong Medical University Zhanjiang 524023, Guangdong, China.
Yuan ZouDepartment of Pathology & Pathophysiology, School of Basic Medicine Sciences, Guangdong Medical University Zhanjiang 524023, Guangdong, China.
Xiaomin LiaoDepartment of Pathology & Pathophysiology, School of Basic Medicine Sciences, Guangdong Medical University Zhanjiang 524023, Guangdong, China.
Shuya ZhangKey Laboratory for Tropical Cardiovascular Diseases Research of Hainan Province, The First Affiliated Hospital of Hainan Medical University Haikou 571199, Hainan, China.
Xiaodian ZhangKey Laboratory for Tropical Cardiovascular Diseases Research of Hainan Province, The First Affiliated Hospital of Hainan Medical University Haikou 571199, Hainan, China.
Rujia LiDepartment of Pathology & Pathophysiology, School of Basic Medicine Sciences, Guangdong Medical University Zhanjiang 524023, Guangdong, China.
Jingci XingDepartment of Pathology & Pathophysiology, School of Basic Medicine Sciences, Guangdong Medical University Zhanjiang 524023, Guangdong, China.
Wei JieDepartment of Pathology & Pathophysiology, School of Basic Medicine Sciences, Guangdong Medical University Zhanjiang 524023, Guangdong, China.
Junli GuoKey Laboratory for Tropical Cardiovascular Diseases Research of Hainan Province, The First Affiliated Hospital of Hainan Medical University Haikou 571199, Hainan, China.
Jingquan LiDepartment of Oncology, The First Affiliated Hospital of Hainan Medical University Haikou 570102, Hainan, China.
Zhihua ShenDepartment of Pathology & Pathophysiology, School of Basic Medicine Sciences, Guangdong Medical University Zhanjiang 524023, Guangdong, China.
Guangdong Medical College · CNHainan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptidyl-prolyl isomerase Pin1 is crucial for cell proliferation, but its role in pulmonary artery remodeling (PAR) is unclear. In the present study, we aimed to evaluate the expression and contribution of Pin1 in PAR. Treatment with Pin1 inhibitor Juglone or Pin1-specific siRNAs ameliorated the expression of Pin1 and proliferating cell nuclear antigen (PCNA) in human pulmonary artery smooth muscle cells (PASMCs)

Indexed as

cell proliferationPin1pulmonary artery remodelingpulmonary artery smooth muscle cellsTGF-β1

Identifiers

PMID34786049
PMCPMC8581927
OpenAlexW3212744746

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.