Evidence map›Paper›PMID 34790194›Full record

ArticleFrontiers in immunology2021

TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion.

Yuan You, Patrick Stelzl, Dana N Joseph, Paulomi B Aldo, Anthony J Maxwell, Nava Dekel, Aihua Liao, Shannon Whirledge, Gil Mor

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 46 citations in OpenAlex.

  1. Trial
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  7. Dengue and severe dengue.Clinical microbiology reviews · 2025
    Review
  8. Review
  9. Article
  10. MIG-6 Plays a Critical Role as a PGR Mediator in Maintaining Epithelial and Stromal Cells for Uterine Receptivity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  11. Review
  12. Review
  13. Article
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  15. Article
  16. The Placenta as an Immunological Environment.British journal of biomedical science · 2025
    Review
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  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Yuan YouC.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, United States.
Patrick StelzlDepartment for Gynecology, Obstetrics and Gynecological Endocrinology, Kepler University Hospital Linz, Johannes Kepler University Linz, Linz, Austria.
Dana N JosephDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, United States.
Paulomi B AldoDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, United States.
Anthony J MaxwellC.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, United States.
Nava DekelDepartment of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel.
Aihua LiaoInstitute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Shannon WhirledgeDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, United States.
Gil MorC.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, United States.
Wayne State University · USYale University · USHuazhong University of Science and Technology · CNKepler Universitätsklinikum · ATWeizmann Institute of Science · IL

Funding

Mechanisms of trophoblast-induced immune modulationR01AI145829 · NIAID · WAYNE STATE UNIVERSITY · PI MOR, GIL G · 2019 to 2023
$1.9M
NIAID NIH HHS R01 AI145829
6 · The paper itself

Abstract

Successful implantation requires the coordinated migration and invasion of trophoblast cells from out of the blastocyst and into the endometrium. This process relies on signals produced by cells in the maternal endometrium. However, the relative contribution of stroma cells remains unclear. The study of human implantation has major technical limitations, therefore the need of

Indexed as

Cell MovementEmbryo ImplantationCell AdhesionCell DifferentiationCell LineEndometriumFemaleHumansInterleukin-17Paracrine CommunicationReceptors, Tumor Necrosis Factor, Type ISecretory PathwaySignal TransductionStromal CellsTrophoblastsTumor Necrosis Factor-alphaInterleukin-17Receptors, Tumor Necrosis Factor, Type ITNF protein, humanTNFRSF1A protein, humanTumor Necrosis Factor-alphacytokineembryo implantationinflammationinvasionmigrationTNF-αtrophoblast

Identifiers

PMID34790194
PMCPMC8591203
OpenAlexW3210769055

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.