ArticleCognitive neurodynamics2021
Closing the loop of DBS using the beta oscillations in cortex.
Article in Cognitive neurodynamics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Current status and future prospects of brain-computer interfaces in the field of neurological disease rehabilitation.Frontiers in rehabilitation sciences · 2026Review
- Deep brain stimulation and Parkinson disease: a bibliometric and visual analysis (1993-2023).Neurosurgical review · 2025Article
- Site-specific seeding of Lewy pathology induces distinct pre-motor cellular and dendritic vulnerabilities in the cortex.Nature communications · 2024Article
- Push-pull effects of basal ganglia network in Parkinson's disease inferred by functional MRI.NPJ Parkinson's disease · 2024Article
- Model-based closed-loop control of thalamic deep brain stimulation.Frontiers in network physiology · 2024Article
- Adaptive Stimulations in a Biophysical Network Model of Parkinson's Disease.International journal of molecular sciences · 2023Article
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Authors and funding
11 authors.
Funding
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Abstract
Cortical information has great importance to reflect the deep brain stimulation (DBS) effects for Parkinson's disease patients. Using cortical activities to feedback is an available closed-loop idea for DBS. Previous studies have demonstrated the pathological beta (12-35 Hz) cortical oscillations can be suppressed by appropriate DBS settings. Thus, here we propose to close the loop of DBS based on the beta oscillations in cortex. By modify the cortico-basal ganglia-thalamic neural loop model, more biologically realistic underlying the Parkinsonian phenomenon is approached. Stimulation results show the proposed closed-loop DBS strategy using cortical beta oscillation as feedback information has more profound roles in alleviating the pathological neural abnormality than the traditional open-loop DBS. Additionally, we compare the stimulation effects with subthalamic nucleus feedback strategy. It is shown that using cortical beta information as the feedback signals can further enlarge the control parameter space based on proportional-integral control structure with a lower energy expenditure. This work may pave the way to optimizing the DBS effects in a closed-loop arrangement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.