Evidence map›Paper›PMID 34790792›Full record

ArticleAnnals of translational medicine2021

Sulfuretted hydrogen ameliorates high dose glucose-induced podocyte apoptosis via orchestrating AMPK/mTOR cascade-mediated anti-apoptotic effects.

Yong Huang, Jie Cheng, Yehua Zhou, Yanhui Zhang, Shuhui Zhou, Qingzhen Li, Lin Peng, Maohong Wang, Weiguo Song, Guoqing Wu

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yong HuangDepartment of Nephrology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Jie ChengDepartment of Nephrology, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Yehua ZhouDepartment of Nephrology, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Yanhui ZhangDepartment of Nephrology, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Shuhui ZhouDepartment of Nephrology, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Qingzhen LiDepartment of Nephrology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Lin PengDepartment of Nephrology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Maohong WangDepartment of Nephrology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Weiguo SongDepartment of Nephrology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Guoqing WuDepartment of Nephrology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine · CNJiangxi University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPodocytes play a pivotal role in the glomerular filtration barrier and contribute to proteinuria and glomerulosclerosis through abnormal apoptosis. Longitudinal studies have indicated the protective properties of hydrogen sulfide (H

methodsHerein, we conducted multifaceted biological analyses to verify the potential function of H

resultsIn this study, we found that glucose-induced podocyte apoptosis could be largely rescued by H

conclusionsFor the first time, we indicated the protective effect and mechanism of H

Indexed as

AMPK/mTORglucose-induced apoptosisPodocyte injuryreactive oxygen species (ROS)sulfuretted hydrogen

Identifiers

PMID34790792
PMCPMC8576736
OpenAlexW3208333388

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.