Evidence map›Paper›PMID 34795404›Full record

ReviewCommunications biology2021

Role of sleep deprivation in immune-related disease risk and outcomes.

Sergio Garbarino, Paola Lanteri, Nicola Luigi Bragazzi, Nicola Magnavita, Egeria Scoditti

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 304 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
304citing papers in PubMed, 5 pooled it
54.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

304 citing papers in PubMed, 5 syntheses or guidelines pooled it, 499 citations in OpenAlex.

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  18. Sleep physiology and critical illness: A narrative review.Journal of the Intensive Care Society · 2026
    Review
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244 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Sergio GarbarinoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal/Child Sciences, University of Genoa, 16132, Genoa, Italy. sgarbarino.neuro@gmail.com.ORCID 0000-0002-8508-552X
Paola LanteriNeurophysiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Nicola Luigi BragazziLaboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, ON, M3J 1P3, Canada.
Nicola MagnavitaPostgraduate School of Occupational Medicine, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.
Egeria ScodittiNational Research Council (CNR), Institute of Clinical Physiology (IFC), 73100, Lecce, Italy.
Fondazione IRCCS Istituto Neurologico Carlo Besta · ITIstituto di Fisiologia Clinica · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Genoa · ITYork University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modern societies are experiencing an increasing trend of reduced sleep duration, with nocturnal sleeping time below the recommended ranges for health. Epidemiological and laboratory studies have demonstrated detrimental effects of sleep deprivation on health. Sleep exerts an immune-supportive function, promoting host defense against infection and inflammatory insults. Sleep deprivation has been associated with alterations of innate and adaptive immune parameters, leading to a chronic inflammatory state and an increased risk for infectious/inflammatory pathologies, including cardiometabolic, neoplastic, autoimmune and neurodegenerative diseases. Here, we review recent advancements on the immune responses to sleep deprivation as evidenced by experimental and epidemiological studies, the pathophysiology, and the role for the sleep deprivation-induced immune changes in increasing the risk for chronic diseases. Gaps in knowledge and methodological pitfalls still remain. Further understanding of the causal relationship between sleep deprivation and immune deregulation would help to identify individuals at risk for disease and to prevent adverse health outcomes.

Indexed as

Disease SusceptibilityImmunityInflammationHumansSleep Deprivation

Identifiers

PMID34795404
PMCPMC8602722
OpenAlexW3211408038

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.