SynthesisBMC infectious diseases2021
Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.
Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph
Synthesis in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Convalescent Plasma Therapy for COVID-19: A Systematic Review and Meta-Analysis on Randomized Controlled Trials.Viruses · 2023Pooled it
- Efficacy and Safety of COVID-19 Treatment Using Convalescent Plasma Transfusion: Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.International journal of environmental research and public health · 2022Pooled it
- The efficiency of convalescent plasma in COVID-19 patients: A systematic review and meta-analysis of randomized controlled clinical trials.Frontiers in immunology · 2022Pooled it
- Convalescent Plasma for Covid-19-Induced ARDS in Mechanically Ventilated Patients.The New England journal of medicine · 2023Trial
- The Relationship Between SARS-CoV-2 Neutralizing Antibody Titers and Avidity in Plasma Collected From Convalescent Nonvaccinated and Vaccinated Blood Donors.The Journal of infectious diseases · 2023Trial
- Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial.BMC infectious diseases · 2022Trial
- Safety and efficacy of convalescent plasma for severe COVID-19: a randomized, single blinded, parallel, controlled clinical study.BMC infectious diseases · 2022Trial
- Convalescent plasma in the treatment of moderate to severe COVID-19 pneumonia: a randomized controlled trial (PROTECT-Patient Trial).Scientific reports · 2022Trial
- A review of bloodstream infections-pathogens, pathogenesis, diagnostic strategies, treatment methods-challenges and future aspects.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Anti-spike IgG Avidity Enhances Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2: A Prospective Study of Primary Infections and Immunizations.The Journal of infectious diseases · 2026Article
- Acute SARS-CoV-2 infection.Nature reviews. Disease primers · 2025Review
- Convalescent plasma therapy for COVID-19 in patients with nasal catheter oxygen therapy.Journal of thoracic disease · 2025Article
- Convalescent plasma therapy and long-term SARS-COV-2 antiviral immune response in a prospective cohort of patients with COVID-19.Current research in microbial sciences · 2025Article
- The effectiveness of convalescent plasma administered on the first day of admission for COVID-19 patients: an open-label randomized controlled trial.Infectious diseases & immunity · 2025Article
- Immunological sub-phenotypes and response to convalescent plasma in COVID-19 induced ARDS: a secondary analysis of the CONFIDENT trial.Annals of intensive care · 2024Article
- Cytokine, Anti-SARS-CoV-2 Antibody, and Neutralizing Antibody Levels in Conventional Blood Donors Who Have Recovered from COVID-19.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024Article
- Review
- Efficacy of COVID-19 Treatments in Intensive Care Unit: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Critical care research and practice · 2024Review
- The role of convalescent plasma and hyperimmune immunoglobulins in the COVID-19 pandemic, including implications for future preparedness.Frontiers in immunology · 2024Review
- Convalescent Plasma as Adjunctive Therapy for Hospitalized Patients with COVID-19: The Co-CLARITY Trial.Acta medica Philippina · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
208 authors at 20 institutions in 26 countries.
Cathrine AxforsMeta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, USA.
Perrine Janiaud *Department of Clinical Research, University Hospital Basel, University of Basel, Spitalstrasse 12, 4031, Basel, Switzerland.
Andreas M SchmittDepartment of Clinical Research, University Hospital Basel, University of Basel, Spitalstrasse 12, 4031, Basel, Switzerland.
Janneke Van't HooftAmsterdam University Medical Center, Amsterdam University, Amsterdam, The Netherlands.
Emily R SmithDepartment of Global Health, Milken Institute School of Public Health, The George Washington University, Washington, USA.
Noah A HaberMeta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, USA.
Akin AbayomiLagos State Ministry of Health, Lagos, Nigeria.
Manal AbduljalilInternal Medicine, Bahrain Defence Force Hospital, Riffa, Bahrain.
Abdulkarim AbdulrahmanMedical Team, National Task Force for Combating the Coronavirus (COVID19), Riffa, Bahrain.
Yeny Acosta-AmpudiaCenter for Autoimmune Diseases Research (CREA), Universidad del Rosario, Bogotá, Colombia.
Manuela Aguilar-GuisadoInfectious Diseases, Microbiology and Preventive Medicine Unit, Hospital Universitario Virgen del Rocío, Seville, Spain.
Farah Al-BeidhSurgery and Cancer, Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK.
Marissa M AlejandriaDepartment of Medicine, Division of Infectious Diseases, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Rachelle N AlfonsoDepartment of Medicine, Division of Hematology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Mohammad AliCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Manaf AlQahtaniMedical Team, National Task Force for Combating the Coronavirus (COVID19), Riffa, Bahrain.
Alaa AlZamrooniInternal Medicine, Salmaniya Medical Complex, Manama, Bahrain.
Juan-Manuel AnayaCenter for Autoimmune Diseases Research (CREA), Universidad del Rosario, Bogotá, Colombia.
Mark Angelo C AngDepartment of Laboratories, Division of Blood Bank, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Ismael F AomarDepartment of Internal Medicine, Hospital Universitario San Cecilio, Granada, Spain.
Luis E ArgumanisBanco de Sangre, Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru.
Alexander AveryanovPulmonary Division, Federal Scientific and Clinical Center of Specialized Medical Care and Medical Technologies of the Federal Medical and Biological Agency, Moscow, Russian Federation.
Vladimir P BaklaushevFundamental Medicine Department, Pulmonology Scientific and Research Institute under Federal Medical and Biological Agency, Moscow, Russian Federation.
Olga BalionisPulmonary Division, Federal Scientific and Clinical Center of Specialized Medical Care and Medical Technologies of the Federal Medical and Biological Agency, Moscow, Russian Federation.
Thomas BenfieldCenter for Research and Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Denmark.
Scott BerryBerry Consultants, Austin, USA.
Nadia BiroccoDepartment of Oncology, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
Lynn B BonifacioDepartment of Medicine, Division of Hematology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Asha C BowenMenzies School of Health Research, Casuarina, Australia.
Abbie BownRare and Imported Pathogens Laboratory, Public Health England, Porton Down, UK.
Carlos Cabello-GutierrezDepartment Research in Virology and Mycology, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.
Bernardo CamachoInstituto Distrital de Ciencia Biotecnología e Investigación en Salud (IDCBIS), Bogotá, Colombia.
Adrian Camacho-OrtizDepartment of Infectious Diseases, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Sally Campbell-LeePathology, University of Illinois at Chicago, Chicago, USA.
Damon H CaoDepartment of Medicine, Division of Nephrology, Henry Ford Hospital, Detroit, USA.
Ana CardesaClinical Department, Red Andaluza de Diseño y Traslacion de Terapias Avanzadas, Sevilla, Spain.
Jose M CarnateDepartment of Laboratories, University of the Philippines-Philippine General Hospital, Manila, Philippines.
German Jr J CastilloDepartment of Medicine, Division of Hematology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Rossana CavalloDepartment of Laboratory Medicine, Unit of Microbiology and Virology, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
Fazle R ChowdhuryInternal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Forhad U H ChowdhuryInternal Medicine, Dhaka Medical College, Dhaka, Bangladesh.
Giovannino CicconeDepartment of Quality and Safety in Health Care, Unit of Clinical Epidemiology, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
Antonella CingolaniInfectious Disease, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Fresthel Monica M ClimacosaDepartment of Medical Microbiology, University of Philippines Manila, Manila, Philippines.
Veerle CompernolleBlood Services, Belgian Red Cross-Flanders, Mechelen, Belgium.
Carlo Francisco N CortezDepartment of Medicine, Division of Hematology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Abel Costa NetoInstituto D'Or de Pesquisa e Ensino (IDOR), São Paulo, Brazil.
Sergio D'AnticoDepartment of Laboratory Medicine, Unit of Transfusion Medicine, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
James DalyAustralian Red Cross Lifeblood, Melbourne, Australia.
Franca DanielleDepartment of Laboratory Medicine, Blood Bank, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
Joshua S DavisMenzies School of Health Research, Casuarina, Australia.
Francesco Giuseppe De RosaDepartment of Medical Sciences, Unit of Infective Diseases, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
Justin T DenholmVictorian Infectious Diseases Service, The Royal Melbourne Hospital, Melbourne, Australia.
Claudia M DenkingerCenter of Infectious Diseases, Division of Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Daniel DesmechtAnimal Pathology, Liège University, Liège, Belgium.
Juan C Díaz-CoronadoDeparment of Internal Medicine, Universidad CES, Medellín, Colombia.
Juan A Díaz Ponce-MedranoCentro Medico Naval, Mexico City, Mexico.
Anne-Françoise DonneauPublic Health Department, Biostatistic, Liège University, Liège, Belgium.
Teresita E DumagayDepartment of Medicine, Division of Hematology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Susanna DunachieCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Cecile C DungogDepartment of Laboratories, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Olufemi ErinosoLagos State University Teaching Hospital, Lagos, Nigeria.
Ivy Mae S EscasaDepartment of Medicine, Division of Hematology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Lise J EstcourtClinical, Research and Development, NHS Blood and Transplant, Oxford, UK.
Amy EvansClinical Trials Unit, NHS Blood and Transplant, Cambridge, UK.
Agnes L M EvasanDepartment of Medicine, Division of Infectious Diseases, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Christian J FareliCENETEC (National Center for Health Technology Excellence), Mexico City, Mexico.
Veronica Fernandez-SanchezBlood Bank, Centro Médico Naval and FES Iztacala UNAM, Mexico City, Mexico.
Claudia GalassiDepartment of Quality and Safety in Health Care, Unit of Clinical Epidemiology, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
Juan E GalloGenoma CES, Universidad CES, Medellín, Colombia.
Patricia J GarciaFacultad de Salud Pública y Administración, Universidad Peruana Cayetano Heredia, Lima, Peru.
Patricia L GarciaServicio de Hemoterapia y Banco de Sangre, Instituto Nacional de Salud del Niño San Borja, Lima, Peru.
Jesus A GarciaDepartment of Haematology, Centro Transfusional Tejidos y Celulas de Granada, Granada, Spain.
Mutien GariglianyAnimal Pathology, Liège University, Liège, Belgium.
Elvira Garza-GonzalezDepartment of Infectious Diseases, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Deonne Thaddeus V GauiranDepartment of Medicine, Division of Hematology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Paula A Gaviria GarcíaInstituto Distrital de Ciencia Biotecnología e Investigación en Salud (IDCBIS), Bogotá, Colombia.
Jose-Antonio Giron-GonzalezDepartment of Infectious Diseases, Hospital Universitario Puerta del Mar, Cádiz, Spain.
David Gómez-AlmaguerDepartment of Hematology, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Anthony C GordonSurgery and Cancer, Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, UK.
André GothotImmunohematology, Liège University Hospital, Liège, Belgium.
Jeser Santiago Grass GuaquetaInstituto Distrital de Ciencia Biotecnología e Investigación en Salud (IDCBIS), Bogotá, Colombia.
Cameron GreenANZIC-RC, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
David GrimaldiIntensive Care Medicine, Cliniques Universitaires de Bruxelles-Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Naomi E HammondThe George Institute for Global Health, Sydney and New Delhi, Sydney, Australia.
Heli HarvalaMicrobiology Services, NHS Blood and Transplant, London, UK.
Francisco M HeraldeDepartment of Biochemistry and Molecular Biology, University of the Philippines, Manila, Philippines.
Jesica HerrickMedicine, Division of Infectious Diseases, Immunology, and International Medicine, University of Illinois at Chicago, Chicago, USA.
Alisa M HigginsANZIC-RC, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Thomas E HillsMedical Research Institute of New Zealand, Wellington, New Zealand.
Jennifer HinesDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Henry Ford Hospital, Detroit, USA.
Karin HolmDivision of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden.
Ashraful HoqueBlood Transfusion, Sheikh Hasina National Institute of Burn and Plastic Surgery, Dhaka, Bangladesh.
Eric HosteIntensive Care Medicine, Gand University Hospital, Gent, Belgium.
Jose M IgnacioDepartment of Neumology and Pulmonology, Hospital Quiron de Marbella, Málaga, Spain.
Alexander V IvanovCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russian Federation.
Maike JanssenDepartment of Hematology, Oncology and Rheumatology, Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany.
Jeffrey H JenningsDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Henry Ford Hospital, Detroit, USA.
Vivekanand JhaThe George Institute for Global Health, Sydney and New Delhi, New Delhi, India.
Ruby Anne N KingDepartment of Biochemistry and Molecular Biology, University of the Philippines, Manila, Philippines.
Jens Kjeldsen-KraghClinical Immunology and Transfusion Medicine, University and Regional Laboratories, Region Skåne, Lund, Sweden.
Paul KlenermanCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Aditya KotechaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Henry Ford Hospital, Detroit, USA.
Fiorella KrappFacultad de Medicina, Instituto de Medicina Tropical Alexander Von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
Luciana LabancaDepartment of Laboratory Medicine, Blood Bank, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
Emma LaingClinical Trials Unit, NHS Blood and Transplant, Cambridge, UK.
Mona Landin-OlssonDepartment of Clinical Sciences, Lund University, Lund, Sweden.
Pierre-François LaterreIntensive Care Medicine, Saint-Luc University Hospital, Brussels, Belgium.
Lyn-Li LimEastern Health, Box Hill, Australia.
Jodor LimDepartment of Medicine, Division of Infectious Diseases, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Oskar LjungquistClinical Sciences, Clinical Infection Medicine, Lund University, Malmo, Sweden.
Jorge M Llaca-DíazDepartment of Clinical Pathology, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Concepción López-RoblesDepartment of Infectious Diseases, Hospital Universitario Virgen de Las Nieves, Granada, Spain.
Salvador López-CárdenasDepartment of Infectious Diseases, Hospital Universitario de Jerez de La Frontera, Jerez de la Frontera, Spain.
Ileana Lopez-PlazaDivision of Transfusion Medicine, Department of Pathology, Henry Ford Hospital, Detroit, USA.
Josephine Anne C LuceroDepartment of Medicine, Division of Hematology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Maria LundgrenClinical Immunology and Transfusion Medicine, University and Regional Laboratories, Region Skåne, Lund, Sweden.
Juan MacíasDepartment of Infectious Diseases, Hospital Universitario de Valme, Sevilla, Spain.
Sandy C MaganitoDepartment of Laboratories, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Anna Flor G MalundoDepartment of Medicine, Division of Infectious Diseases, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Rubén D ManriqueEpidemiology and Biostatistics Research Group, Universidad CES, Medellín, Colombia.
Paola M ManziniDepartment of Laboratory Medicine, Unit of Transfusion Medicine, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
Miguel MarcosDepartment of Internal Medicine, Hospital Quiron de Malaga, Málaga, Spain.
Ignacio MarquezDepartment of Infectious Diseases, Hospital Regional Universitario de Malaga, Málaga, Spain.
Francisco Javier Martínez-MarcosInfectious Disease Unit, Hospital Universitario Juan Ramon Jimenez, Huelva, Spain.
Ana M MataDepartment of Internal Medicine, Hospital San Juan de Dios del Aljarafe, Bormujos, Spain.
Colin J McArthurDepartment of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand.
Zoe K McQuiltenDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.
Bryan J McVerryDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA.
David K MenonUniversity Division of Anaesthesia, Addenbrooke's Hospital Cambridge, University of Cambridge, Cambridge, UK.
Geert MeyfroidtIntensive Care Medicine, Leuven University Hospital, Leuven, Belgium.
Ma Angelina L MirasolDepartment of Medicine, Division of Hematology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Benoît MissetIntensive Care Medicine, Liège University Hospital, Liège, Belgium.
James S MoltonWestern Health, Melbourne, Australia.
Alric V MondragonDepartment of Medicine, Division of Allergy and Immunology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Diana M MonsalveCenter for Autoimmune Diseases Research (CREA), Universidad del Rosario, Bogotá, Colombia.
Parastoo Moradi ChoghakabodiThalassemia and Hemoglobinopathy Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Susan C MorpethMiddlemore Hospital, Auckland, New Zealand.
Paul R MounceyClinical Trials Unit, Intensive Care National Audit and Research Centre, London, UK.
Michel MoutschenIntensive Care Medicine, Liège University Hospital, Liège, Belgium.
Carsten Müller-TidowDepartment of Hematology, Oncology and Rheumatology, Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany.
Erin MurphyDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Henry Ford Hospital, Detroit, USA.
Tome NajdovskiBlood Services, Red Cross, Suarlée, Belgium.
Alistair D NicholSchool of Medicine and Medical Sciences, University College Dublin-Clinical Research Centre, University College Dublin, Dublin, Ireland.
Henrik NielsenDepartment of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.
Richard M NovakMedicine, Division of Infectious Diseases, Immunology, and International Medicine, University of Illinois at Chicago, Chicago, USA.
Matthew V N O'SullivanInstitute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead, Australia.
Julian OlallaDepartment of Internal Medicine, Hospital Costa del Sol, Málaga, Spain.
Akin OsibogunCollege of Medicine, University of Lagos, Lagos, Nigeria.
Bodunrin OsikomaiyaLagos State Ministry of Health, Lagos, Nigeria.
Salvador OyonarteDepartment of Infectious Diseases, Centro Transfusional Tejidos y Celulas de Sevilla, Sevilla, Spain.
Juan M Pardo-OviedoHospital Universitario Mayor Méderi, Universidad del Rosario, Bogotá, Colombia.
Mahesh C PatelMedicine, Division of Infectious Diseases, Immunology, and International Medicine, University of Illinois at Chicago, Chicago, USA.
David L PatersonCentre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Australia.
Carlos A Peña-PerezAdult Intensive Care Unit, Centro Medico Naval, Mexico City, Mexico.
Angel A Perez-CalatayudAcute Medicine, Head ICU, Hospital General de Mexico, Mexico City, Mexico.
Eduardo Pérez-AlbaDepartment of Infectious Diseases, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Anastasia PerkinaPulmonary Division, Federal Scientific and Clinical Center of Specialized Medical Care and Medical Technologies of the Federal Medical and Biological Agency, Moscow, Russian Federation.
Naomi PerryDoherty Department, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Mandana PouladzadehEmergency Medicine Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Inmaculada PoyatoDepartment of Internal Medicine, Hospital Universitario Torrecardenas, Almería, Spain.
David J PriceDoherty Department, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Anne Kristine H QueroDepartment of Medicine, Division of Hematology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Md M RahmanInternal Medicine, Dhaka Medical College, Dhaka, Bangladesh.
Md S RahmanPharmacology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Mayur RameshDepartment of Internal Medicine, Division of Infectious Diseases, Henry Ford Hospital, Detroit, USA.
Carolina Ramírez-SantanaCenter for Autoimmune Diseases Research (CREA), Universidad del Rosario, Bogotá, Colombia.
Magnus RasmussenDivision of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden.
Megan A ReesDepartment of Medicine, University of Melbourne, Melbourne, Australia.
Eduardo RegoInstituto D'Or de Pesquisa e Ensino (IDOR), São Paulo, Brazil.
Jason A RobertsHospital Universitario Mayor Méderi, Universidad del Rosario, Bogotá, Colombia.
David J RobertsRadcliffe Department of Medicine and BRC Haematology Theme, University of Oxford, Oxford, UK.
Yhojan RodríguezCenter for Autoimmune Diseases Research (CREA), Universidad del Rosario, Bogotá, Colombia.
Jesús Rodríguez-BañoInfectious Diseases and Clinical Microbiology Unit, Hospital Universitario Virgen Macarena, Sevilla, Spain.
Benjamin A RogersMonash University, Melbourne, Australia.
Manuel RojasCenter for Autoimmune Diseases Research (CREA), Universidad del Rosario, Bogotá, Colombia.
Alberto RomeroDepartment of Infectious Diseases, Hospital Universitario de Puerto Real, Cádiz, Spain.
Kathryn M RowanIntensive Care National Audit and Research Centre (ICNARC), London, UK.
Fabio SacconaDepartment of Quality and Safety in Health Care, Unit of Clinical Epidemiology, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
Mehdi SafdarianNanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Maria Clariza M SantosDepartment of Medicine, Division of Hematology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Joe SasadeuszVictorian Infectious Diseases Service, The Royal Melbourne Hospital, Melbourne, Australia.
Gitana ScozzariDepartment of Medical Hospital Direction, Unit of Medical Direction, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
Manu Shankar-HariSt Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Gorav SharmaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Henry Ford Hospital, Detroit, USA.
Thomas SnellingMenzies School of Health Research, Casuarina, Australia.
Alonso SotoFacultad de Medicina Humana, Instituto de Investigación en Ciencias Biomédicas (INICIB), Universidad Ricardo Palma, Lima, Peru.
Pedrito Y TagayunaDepartment of Laboratories, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Amy TangPublic Health Sciences, Henry Ford Hospital, Detroit, USA.
Geneva TatemDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Henry Ford Hospital, Detroit, USA.
Luciana TeofiliTransfusion Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Steven Y C TongVictorian Infectious Diseases Service, The Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Alexis F TurgeonDepartment of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Université Laval, Quebec City, QC, Canada.
Januario D VelosoDepartment of Medicine, Division of Hematology, University of the Philippines-Philippine General Hospital, Manila, Philippines.
Balasubramanian VenkateshThe George Institute for Global Health, Sydney and New Delhi, Sydney, Australia.
Yanet Ventura-EnriquezBlood Bank, Centro Medico Naval, Mexico City, Mexico.
Steve A WebbSchool of Medicine and Medical Sciences, University College Dublin-Clinical Research Centre, University College Dublin, Dublin, Ireland.
Lothar WieseDepartment of Infectious Diseases, Zealand University Hospital, Roskilde, Denmark.
Christian WikénInfectious Diseases, Skåne University Hospital, Lund, Sweden.
Erica M WoodDepartment of Clinical Haematology, Monash Health, Melbourne, Australia.
Gaukhar M YusubalievaCell Culture Laboratory, Biomedical Research, Federal Scientific and Clinical Center of Specialized Medical Care and Medical Technologies of the Federal Medical and Biological Agency, Moscow, Russian Federation.
Kai ZacharowskiDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Ryan ZarychanskiDepartment of Internal Medicine, Critical Care and Hematology/Medical Oncology, University of Manitoba, Winnipeg, Canada.
Nina KhannaDivision of Infectious Diseases and Hospital Hygiene and Infection Biology Laboratory, University Hospital Basel and University of Basel, Basel, Switzerland.
David MoherCentre for Journalology, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Steven N GoodmanMeta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, USA.
John P A IoannidisMeta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, USA.
Lars G HemkensMeta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, USA. lars.hemkens@usb.ch.
Philippine General Hospital · PHAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITHenry Ford Hospital · USUniversidad del Rosario · COLund University · SEFederal Medical-Biological Agency · RUUniversidad Autónoma de Nuevo León · MXNHS Blood and Transplant · GBUniversity of Illinois Chicago · USUniversity of Liège · BEUniversity of Oxford · GBAhvaz Jundishapur University of Medical Sciences · IRBangladesh Medical University · BDCentro Médico ABC · MXClínica CES · COImperial College London · GBInstituto Nacional de Salud del Niño · PEMonash University · AUPeter Doherty Institute · AUProtein Metrics (United States) · US
Funding
Swiss National Science Foundation 31CA30_196190
Abstract
backgroundConvalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ).
methodsIn this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence.
resultsA total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I
conclusionsConvalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care.
Indexed as
COVID-19COVID-19 SerotherapyHumansImmunization, PassiveRandomized Controlled Trials as TopicSARS-CoV-2Treatment OutcomeConvalescent plasmaCOVID-19Meta-analysisSARS-CoV-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.