Evidence map›Paper›PMID 34801617›Full record

ReviewAdvanced drug delivery reviews2022

Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound.

Scott Schoen, M Sait Kilinc, Hohyun Lee, Yutong Guo, F Levent Degertekin, Graeme F Woodworth, Costas Arvanitis

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced drug delivery reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
  2. Review
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  4. Focused ultrasound for brain metastases.Neuro-oncology advances · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Scott SchoenWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
M Sait KilincSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Hohyun LeeWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Yutong GuoWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
F Levent DegertekinWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Graeme F WoodworthDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, College Park, MD 20742, USA; Fischell Department of Bioengineering A. James Clarke School of Engineering, University of Maryland, USA.
Costas ArvanitisWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA. Electronic address: costas.arvanitis@gatech.edu.
Georgia Institute of Technology · USUniversity of Maryland, Baltimore · US

Funding

"Transcranial FUS therapy with closed-loop US image guidance and circulating tumor DNAR37CA239039 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Konstantinos-Costas Arvanitis · 2020 to 2026
$3.3M
Enhanced intra-arterial drug delivery to the brain after blood brain barrier opening: comparison between osmotic and MRI-guided focused ultrasound opening techniquesR21NS118232 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI PEARL, MONICA SMITH · 2021 to 2022
$457k
MRgFUS-enabled non-invasive interrogation of malignant glioma via circulating tumor DNAR21NS113016 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BETTEGOWDA, CHETAN, WOODWORTH, GRAEME F · 2019 to 2019
$454k
NCI NIH HHS R37 CA239039NINDS NIH HHS R21 NS113016NINDS NIH HHS R21 NS118232
6 · The paper itself

Abstract

Brain tumors are particularly challenging malignancies, due to their location in a structurally and functionally distinct part of the human body - the central nervous system (CNS). The CNS is separated and protected by a unique system of brain and blood vessel cells which together prevent most bloodborne therapeutics from entering the brain tumor microenvironment (TME). Recently, great strides have been made through microbubble (MB) ultrasound contrast agents in conjunction with ultrasound energy to locally increase the permeability of brain vessels and modulate the brain TME. As we elaborate in this review, this physical method can effectively deliver a wide range of anticancer agents, including chemotherapeutics, antibodies, and nanoparticle drug conjugates across a range of preclinical brain tumors, including high grade glioma (glioblastoma), diffuse intrinsic pontine gliomas, and brain metastasis. Moreover, recent evidence suggests that this technology can promote the effective delivery of novel immunotherapeutic agents, including immune check-point inhibitors and chimeric antigen receptor T cells, among others. With early clinical studies demonstrating safety, and several Phase I/II trials testing the preclinical findings underway, this technology is making firm steps towards shaping the future treatments of primary and metastatic brain cancer. By elaborating on its key components, including ultrasound systems and MB technology, along with methods for closed-loop spatial and temporal control of MB activity, we highlight how this technology can be tuned to enable new, personalized treatment strategies for primary brain malignancies and brain metastases.

Indexed as

Drug Delivery SystemsAnimalsAntineoplastic AgentsBrain NeoplasmsGliomaHumansMicrobubblesSonicationTumor MicroenvironmentAntineoplastic AgentsBlood brain barrierBlood tumor barrierBrain cancerDrug deliveryFocused ultrasoundMicro-bubblesUltrasound Immunomodulation

Identifiers

PMID34801617
PMCPMC8724442
OpenAlexW3214501402

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.