Evidence map›Paper›PMID 34804889›Full record

ArticleGland surgery2021

Protective effect of Dachengqi decoction on the pancreatic microcirculatory system in severe acute pancreatitis by down-regulating HMGB-TLR-4-IL-23-IL-17A mediated neutrophil activation by targeting SIRT1.

Jia Wang, Yang Zou, Dan Chang, Da-Qing Hong, Jiong Zhang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gland surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Lysine acetylation and its role in the pathophysiology of acute pancreatitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jia Wang *General Practice Center, Sichuan Provincial People's Hospital & Sichuan Academy of Sciences, University of Electronic Science and Technology, Chengdu, China.
Yang Zou *Division of Nephrology, Sichuan Provincial People's Hospital & Sichuan Academy of Sciences, University of Electronic Science and Technology, Chengdu, China.
Dan ChangDivision of Nephrology, Sichuan Provincial People's Hospital & Sichuan Academy of Sciences, University of Electronic Science and Technology, Chengdu, China.
Da-Qing HongDivision of Nephrology, Sichuan Provincial People's Hospital & Sichuan Academy of Sciences, University of Electronic Science and Technology, Chengdu, China.
Jiong ZhangDivision of Nephrology, Sichuan Provincial People's Hospital & Sichuan Academy of Sciences, University of Electronic Science and Technology, Chengdu, China.
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDachengqi decoction (DCQD), one of classic prescription of Chinese herbal medicine has been widely used in clinic to treat severe acute pancreatitis (SAP). The damage of pancreatic microcirculation plays key pathogenesis of SAP. However, little is known about the molecular pharmacological activity of DCQD on pancreatic microcirculation in SAP.

methodsSodium taurodeoxycholate and cerulein were used to establish model of SAP in vitro and

results

conclusionsDCQD treatment improves SAP-induced pancreatic microcirculatory dysfunction by inhibiting neutrophil-mediated inflammation via inactivating HMGB1-TLR-4-IL-23-IL-17A signaling by targeting SIRT1.

Indexed as

Dachengqi decoction (DCQD)HMGB1-TLR-4-IL-23-IL-17Aneutrophilpancreatic microcirculatorySevere acute pancreas (SAP)

Identifiers

PMID34804889
PMCPMC8575701
OpenAlexW3179084242

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.