Evidence map›Paper›PMID 34805091›Full record

ReviewFrontiers in chemistry2021

Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against

Sun Liu Rei Yan, Felipe Wakasuqui, Xiaochen Du, Matthew R Groves, Carsten Wrenger

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Sun Liu Rei YanUnit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences-ICB, University of São Paulo, São Paulo, Brazil.
Felipe WakasuquiUnit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences-ICB, University of São Paulo, São Paulo, Brazil.
Xiaochen DuStructural Biology in Drug Design, Department of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
Matthew R GrovesStructural Biology in Drug Design, Department of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
Carsten WrengerUnit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences-ICB, University of São Paulo, São Paulo, Brazil.
Universidade de São Paulo · BRUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very distinct microorganisms such as

Indexed as

Lipoic acidLipoic acid (LA)lipoylationmalariaPlasmodiumprotein lipoylationS. aureus

Identifiers

PMID34805091
PMCPMC8600131
OpenAlexW3209811994

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.