Evidence map›Paper›PMID 34808192›Full record

ArticleJournal of lipid research2022

Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation.

Pallavi Mukherjee, Arnab Chattopadhyay, Victor Grijalva, Nasrin Dorreh, Venu Lagishetty, Jonathan P Jacobs, Bethan L Clifford, Thomas Vallim, Julia J Mack, Mohamad Navab and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Pallavi MukherjeeDivision of Cardiology, Department of Medicine, Los Angeles, CA, USA.
Arnab ChattopadhyayDivision of Cardiology, Department of Medicine, Los Angeles, CA, USA.
Victor GrijalvaDivision of Cardiology, Department of Medicine, Los Angeles, CA, USA.
Nasrin DorrehDivision of Cardiology, Department of Medicine, Los Angeles, CA, USA.
Venu LagishettyThe Vatche and Tamar Manoukian Division of Digestive Diseases, Los Angeles, CA, USA; UCLA Microbiome Center, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Jonathan P JacobsThe Vatche and Tamar Manoukian Division of Digestive Diseases, Los Angeles, CA, USA; UCLA Microbiome Center, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; The Division of Gastroenterology, Hepatology and Parenteral Nutrition, Veterans Administration Greater Los Angeles Healthcare System Los Angeles, Los Angeles, CA, USA.
Bethan L CliffordDepartment of Biological Chemistry, Los Angeles, CA, USA.
Thomas VallimDivision of Cardiology, Department of Medicine, Los Angeles, CA, USA; Department of Biological Chemistry, Los Angeles, CA, USA.
Julia J MackDivision of Cardiology, Department of Medicine, Los Angeles, CA, USA.
Mohamad NavabDivision of Cardiology, Department of Medicine, Los Angeles, CA, USA.
Srinivasa T ReddyDivision of Cardiology, Department of Medicine, Los Angeles, CA, USA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: sreddy@mednet.ucla.edu.
Alan M FogelmanDivision of Cardiology, Department of Medicine, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Targeting the Enterocyte to Prevent Vascular InflammationR01HL148286 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 2019 to 2022
$2.3M
Modulation of the Intestinal Microbiome in Obesity by a High Protein DietIK2CX001717 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI JACOBS, JONATHAN PATRICK · 2018 to 2023
–
CSRD VA IK2 CX001717NHLBI NIH HHS R01 HL148286NIDDK NIH HHS P30 DK041301
6 · The paper itself

Abstract

We previously reported that adding a concentrate of transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F) to a Western diet (WD) ameliorated systemic inflammation. To determine the mechanism(s) responsible for these observations, Ldlr

Indexed as

DysbiosisInflammationJejunumOxidation-ReductionPhospholipidsAnimalsMaleMiceMucusPhospholipidsAkkermansia muciniphilaApolipoprotein A-I (apoA-I) mimetic peptidesatherosclerosisgoblet cellsInterleukins 36 (IL-36), 23 (IL-23), and 22 (IL-22)lipopolysaccharide (LPS)mucin 2 (Muc2)Paneth cellsregenerating islet-derived family members 3 alpha (Reg3a), 3 beta (Reg3b), and 3 gamma (Reg3g)surfactant A

Identifiers

PMID34808192
PMCPMC8953663
OpenAlexW3216484837

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.