Observational studyArteriosclerosis, thrombosis, and vascular biology2022
Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction.
Open access · bronzeAbstract readObservational Study
In one paragraph
Observational study in Arteriosclerosis, thrombosis, and vascular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
What it found
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The trial behind it
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Combined Assessment of Serum dp-ucMGP and Albumin in Relation to All-Cause and Cardiovascular Mortality in Hemodialysis Patients.International journal of molecular sciences · 2026Observational
- Interleukin-1β Drives Disease Progression in Arrhythmogenic Cardiomyopathy.JACC. Basic to translational science · 2026Article
- Dephospho-Uncarboxylated Matrix Gla-Protein Is Associated With Adverse Outcomes in Heart Failure.Circulation. Heart failure · 2026Article
- Vitamin K and muscle health: mechanisms and clinical perspectives in sarcopenia and beyond: narrative review.Frontiers in nutrition · 2026Review
- Adipokines and Vascular Modulators in CKM: Emerging Biomarkers as Diagnostic and Therapeutic Targets.International journal of molecular sciences · 2025Review
- Identification of novel biomarkers and drug targets for frailty-related skeletal muscle aging: a multi-omics study.QJM : monthly journal of the Association of Physicians · 2025Article
- Rapamycin reduces mineral density and promotes beneficial vascular remodeling in a murine model of severe medial arterial calcification.American journal of physiology. Heart and circulatory physiology · 2025Article
- Rapamycin Reduces Mineral Density and Promotes Beneficial Vascular Remodeling in a Murine Model of Severe Medial Arterial Calcification.bioRxiv : the preprint server for biology · 2025Article
- Association between insulin resistance indices and outcomes in patients with heart failure with preserved ejection fraction.Cardiovascular diabetology · 2025Article
- Interleukin-1β Drives Disease Progression in Arrhythmogenic Cardiomyopathy.bioRxiv : the preprint server for biology · 2024Article
- Metabolites and metabolism in vascular calcification: links between adenosine signaling and the methionine cycle.American journal of physiology. Heart and circulatory physiology · 2024Review
- Ischemic cardiac stromal fibroblast-derived protein mediators in the infarcted myocardium and transcriptomic profiling at single cell resolution.Functional & integrative genomics · 2024Article
- Therapeutic targets for muscle weakness in older adults: proteome-wide Mendelian randomization and colocalization analyses.The journal of nutrition, health & aging · 2024Article
- Transcriptional regulation of the postnatal cardiac conduction system heterogeneity.Nature communications · 2024Article
- Tracking of Infectious Diseases and Deadly Injuries through Signs Observed in Excavated Human Skeletons of 2000 BC/Iron Age in Iran.Iranian journal of public health · 2024Article
- Extrahepatic Vitamin K-Dependent Gla-Proteins-Potential Cardiometabolic Biomarkers.International journal of molecular sciences · 2024Review
- Roles of vitamin K‑dependent protein in biomineralization (Review).International journal of molecular medicine · 2024Review
- Inactive Matrix Gla Protein in Relation to Renal and Cardiac Functions and Cardiac Valvular Calcification Among Type 2 Diabetes Patients.Clinical medicine insights. Endocrinology and diabetes · 2023Article
- Serum biomarkers for arterial calcification in humans: A systematic review.Bone reports · 2022Review
- Matrix GIa Protein, Large Artery Stiffness, and the Risk of Heart Failure With Preserved Ejection Fraction.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
Corrections and comments
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Authors and funding
31 authors at 9 institutions in 2 countries.
Rajeev Malhotra *Cardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).ORCID 0000-0003-0120-4630
Christopher J Nicholson *Cardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).ORCID 0000-0002-5051-4654
Dongyu WangCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).
Vijeta BhambhaniCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).
Samantha PaniaguaCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).
Charles SlocumCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).
Haakon H SigurslidCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).
Christian L Lino CardenasCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).ORCID 0000-0001-5491-4375
Rebecca LiCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).ORCID 0000-0002-1567-9541
Sophie L BoerboomCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).ORCID 0000-0002-7101-6072
Yin-Ching ChenMartinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown (Y.C.C., C.N.).ORCID 0000-0002-9916-2207
Shih-Jen HwangFramingham Heart Study, MA (S.J.H., C.Y., E.J.B., M.G.L., S.C., D.L.).ORCID 0000-0002-2129-5704
Chen YaoFramingham Heart Study, MA (S.J.H., C.Y., E.J.B., M.G.L., S.C., D.L.).
Fumito IchinoseDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston (F.I., D.B.B., W.M.Z.).ORCID 0000-0003-4535-1632
Donald B BlochDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston (F.I., D.B.B., W.M.Z.).
Mark E LindsayCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).ORCID 0000-0001-6724-7938
Gregory D LewisCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).ORCID 0000-0001-8108-8240
Jayashri R AragamWest Roxbury VA Hospital, Harvard Medical School, Boston, MA (J.R.A.).
Udo HoffmannDepartment of Radiology, Massachusetts General Hospital, Boston (U.H.).
Gary F MitchellCardiovascular Engineering, Inc, Norwood, MA (G.F.M.).ORCID 0000-0001-5643-3145
Naomi M HamburgEvans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, MA (N.M.H.).ORCID 0000-0001-5504-5589
Ramachandran S VasanDepartment of Epidemiology, Boston University School of Public Health & Sections of Preventive Medicine and Epidemiology and Cardiology (R.S.V., E.J.B.), Boston University School of Public Health, MA.
Emelia J BenjaminFramingham Heart Study, MA (S.J.H., C.Y., E.J.B., M.G.L., S.C., D.L.).ORCID 0000-0003-4076-2336
Martin G LarsonFramingham Heart Study, MA (S.J.H., C.Y., E.J.B., M.G.L., S.C., D.L.).
Warren M ZapolDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston (F.I., D.B.B., W.M.Z.).ORCID 0000-0002-0359-3660
Susan ChengFramingham Heart Study, MA (S.J.H., C.Y., E.J.B., M.G.L., S.C., D.L.).ORCID 0000-0002-4977-036X
Jason D RohCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).
Christopher J O'DonnellU.S. Department of Veterans Affairs, Boston, MA (C.J.O.).
Christopher NguyenCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).ORCID 0000-0003-1475-2329
Daniel LevyFramingham Heart Study, MA (S.J.H., C.Y., E.J.B., M.G.L., S.C., D.L.).ORCID 0000-0003-1843-8724
Jennifer E HoCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.M., C.J.N., D.W., V.B., S.P., C.S., H.H.S., C.L.L.C., R.L., S.L.B., M.E.L., G.D.L., J.D.R., C.N., J.E.H.).ORCID 0000-0002-7987-4768
United States Nuclear Regulatory Commission · USBoston University · USFramingham Heart Study · USMassachusetts General Hospital · USCardiovascular Institute of the South · USDepartment of Veterans Affairs · AUMassachusetts Eye and Ear Infirmary · USNorwood Hospital · USRoxbury Community College · US
Funding
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MCardiac microstructure and the immune-inflammatory response to SARS-CoV-2R01HL131532 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN, LI, DEBIAO · 2016 to 2025
$6.6MThe Role of Histone Deacetylase 9 in Vascular CalcificationR01HL142809 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MALHOTRA, RAJEEV · 2018 to 2022
$4.0MSerial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRIR01HL151704 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, CHRISTOPHER T · 2020 to 2024
$3.4MMediators of Systemic Inflammation and Heart Failure Risk in the CommunityR01HL143227 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN · 2019 to 2022
$3.3MVentricular-vascular coupling in the elderly: lifecourse determinants, trajectories, and prognostic significanceR01HL142983 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHENG, SUSAN, MITCHELL, GARY FRANK · 2019 to 2022
$3.2MAFGen Consortium: Atrial Fibrillation Genomics to Functional AnalysesR01HL128914 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2015 to 2018
$3.1MEicosanoid Profiles as Determinants of HFpEFR01HL140224 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HO, JENNIFER E · 2018 to 2021
$3.1MThe Association of Metabolic Disease and Pulmonary HypertensionR01HL134893 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HO, JENNIFER E · 2017 to 2021
$2.9MCharacterization of Functional Iron Deficiency and Repletion in Heart Failure with Preserved Ejection FractionR01HL159514 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, GREGORY DYER, MALHOTRA, RAJEEV · 2021 to 2024
$2.5MFHS-NEXT - Framingham Novel EXam using TechnologyR01HL141434 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., MCMANUS, DAVID D. · 2019 to 2022
$2.5MNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K24 HL153669NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL060040NHLBI NIH HHS R01 HL070100NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL128914NHLBI NIH HHS R01 HL131532NHLBI NIH HHS R01 HL134168NHLBI NIH HHS R01 HL134893NHLBI NIH HHS R01 HL140224NHLBI NIH HHS R01 HL141434NHLBI NIH HHS R01 HL142809NHLBI NIH HHS R01 HL142983NHLBI NIH HHS R01 HL143227NHLBI NIH HHS R01 HL151704NHLBI NIH HHS R01 HL159514NIA NIH HHS K76 AG064328
Abstract
objectiveArterial stiffness is a risk factor for cardiovascular disease, including heart failure with preserved ejection fraction (HFpEF). MGP (matrix Gla protein) is implicated in vascular calcification in animal models, and circulating levels of the uncarboxylated, inactive form of MGP (ucMGP) are associated with cardiovascular disease-related and all-cause mortality in human studies. However, the role of MGP in arterial stiffness is uncertain. Approach and Results: We examined the association of ucMGP levels with vascular calcification, arterial stiffness including carotid-femoral pulse wave velocity (PWV), and incident heart failure in community-dwelling adults from the Framingham Heart Study. To further investigate the link between MGP and arterial stiffness, we compared aortic PWV in age- and sex-matched young (4-month-old) and aged (10-month-old) wild-type and Mgp
conclusionsThis translational study demonstrates an association between ucMGP levels and arterial stiffness and future HFpEF in a large observational study, findings that are substantiated by experimental studies showing that mice with Mgp heterozygosity develop arterial stiffness. Taken together, these complementary study designs suggest a potential role of therapeutically targeting MGP in HFpEF.
Indexed as
Vascular StiffnessAnimalsBlood PressureCalcium-Binding ProteinsExtracellular Matrix ProteinsFemaleGene DeletionHeart FailureHumansLongitudinal StudiesMaleMatrix Gla ProteinMiceMice, Inbred C57BLMiddle AgedProspective StudiesCalcium-Binding ProteinsExtracellular Matrix ProteinsMatrix Gla Proteinarterial stiffnessbiomarkerheart failurehypertensionmicepulse wave velocity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.