Evidence mapPaperPMID 34812127Full record

Trial reportGut microbes

Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome.

Clara Depommier, Amandine Everard, Céline Druart, Dominique Maiter, Jean-Paul Thissen, Audrey Loumaye, Michel P Hermans, Nathalie M Delzenne, Willem M de Vos, Patrice D Cani

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 50 citations in OpenAlex.

  1. Gut microbes · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. International journal of molecular sciences · 2025
    Review
  7. Review
  8. Review
  9. Gut Microbiota-Derived Metabolites Orchestrate Metabolic Reprogramming in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Frontiers.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Journal of medicine and life · 2024
    Article
  14. Review
  15. Review
  16. Research trends of next generation probiotics.Food science and biotechnology · 2024
    Review
  17. Effects of dietary fibre on metabolic health and obesity.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  18. Review
  19. Article
  20. International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Clara DepommierMetabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (Welbio), UCLouvain, Université Catholique De Louvain, Brussels, Belgium.
Amandine EverardMetabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (Welbio), UCLouvain, Université Catholique De Louvain, Brussels, Belgium.
Céline DruartMetabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (Welbio), UCLouvain, Université Catholique De Louvain, Brussels, Belgium.
Dominique MaiterPôle Edin, Institut De Recherches Expérimentales Et Cliniques, UCLouvain, Université Catholique De Louvain, Brussels, Belgium.
Jean-Paul ThissenPôle Edin, Institut De Recherches Expérimentales Et Cliniques, UCLouvain, Université Catholique De Louvain, Brussels, Belgium.
Audrey LoumayePôle Edin, Institut De Recherches Expérimentales Et Cliniques, UCLouvain, Université Catholique De Louvain, Brussels, Belgium.
Michel P HermansPôle Edin, Institut De Recherches Expérimentales Et Cliniques, UCLouvain, Université Catholique De Louvain, Brussels, Belgium.
Nathalie M DelzenneMetabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (Welbio), UCLouvain, Université Catholique De Louvain, Brussels, Belgium.ORCID 0000-0003-2115-6082
Willem M de VosLaboratory of Microbiology, Wageningen University, Wageningen, The Netherland.ORCID 0000-0002-0273-3166
Patrice D CaniMetabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (Welbio), UCLouvain, Université Catholique De Louvain, Brussels, Belgium.ORCID 0000-0003-2040-2448
Walloon Excellence in Lifesciences and Biotechnology · BECliniques Universitaires Saint-Luc · BEUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reduction of

Indexed as

AdolescentAdultAgedAkkermansiaAmino AcidsCarnitineGlycolysisHumansInsulin ResistanceKetone BodiesLipid MetabolismLiverMetabolic SyndromeMetabolomeMiddle AgedProbioticsacylcarnitineAmino AcidsCarnitineKetone Bodiesacylcarnitinesamino-acidsA. muciniphilahumanketone bodiesmetabolic syndromemetabolomicobesityprediabetes

Identifiers

PMID34812127
PMCPMC8632301
OpenAlexW3217769874

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.