Evidence map›Paper›PMID 34813985›Full record

ArticleCell calcium2022

Mutation in RyR2-FKBP Binding site alters Ca

José-Carlos Fernández-Morales, Yanli Xia, Taylor J Renzo, Xiao-Hua Zhang, Martin Morad

Open access · greenAbstract read
In one paragraph

Article in Cell calcium, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
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  8. Arrhythmogenic mechanism of a novel ryanodine receptor mutation underlying sudden cardiac death.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

José-Carlos Fernández-MoralesCardiac Signaling Center of MUSC, USC and Clemson, Charleston, SC, 29425 United States of America.
Yanli XiaCardiac Signaling Center of MUSC, USC and Clemson, Charleston, SC, 29425 United States of America.
Taylor J RenzoCardiac Signaling Center of MUSC, USC and Clemson, Charleston, SC, 29425 United States of America.
Xiao-Hua ZhangCardiac Signaling Center of MUSC, USC and Clemson, Charleston, SC, 29425 United States of America.
Martin MoradCardiac Signaling Center of MUSC, USC and Clemson, Charleston, SC, 29425 United States of America; Department of Pharmacology, Georgetown University Medical Center, Washington, DC, United States of America. Electronic address: moradm@musc.edu.
Georgetown University Medical Center · US

Funding

Functional implications of CPVT1-associated RyR2 mutations in human cardiomyocytesR01HL153504 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MORAD, MARTIN, YAMAGUCHI, NAOHIRO · 2021 to 2024
$2.0M
Functional implications of RyR2 mutations in human cardiomyocytesR56HL147054 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MORAD, MARTIN, YAMAGUCHI, NAOHIRO · 2019 to 2019
$607k
NHLBI NIH HHS R01 HL153504NHLBI NIH HHS R56 HL147054
6 · The paper itself

Abstract

aimsTo gain insights into FKBP regulation of cardiac ryanodine receptor (RyR2) and Ca METHODS AND

resultsCa

conclusionsThe more frequent spontaneous Ca

Indexed as

Calcium SignalingInduced Pluripotent Stem CellsRyanodine Receptor Calcium Release ChannelBinding SitesCalciumHumansMutationMyocytes, CardiacSarcoplasmic ReticulumTacrolimus Binding ProteinsCalciumRyanodine Receptor Calcium Release ChannelRyR2 protein, humanTacrolimus Binding ProteinsCICR gainCRISPR/Cas9FKBP binding siteHuman induced Pluripotent Stem CellsRyanodine receptor mutationSkeletal myopathy

Identifiers

PMID34813985
PMCPMC8752506
OpenAlexW3212917415

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.