ArticleProceedings of the National Academy of Sciences of the United States of America2021
BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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0cells of the map it votes in
24citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
- BAP1 Loss in Pleural Mesothelioma Is Associated With Reduced Soluble CCL2 in Patient Effusion, Abrogated CCL2-Mediated Monocyte Recruitment In Vitro.JTO clinical and research reports · 2026Article
- Damage-Associated Molecular Patterns in Mesothelioma: Drivers of Inflammation and Therapeutic Targets.International journal of molecular sciences · 2026Review
- Review
- Tumor suppressor BAP1 emerges as a key regulator of metabolism and cell death in tumors.Frontiers in cell and developmental biology · 2026Review
- Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Review
- Lack of resolution of inflammation marks malignant pleural mesothelioma progression.Cancer drug resistance (Alhambra, Calif.) · 2026Article
- Review
- HMGB1 as a Key Mediator in Malignant Mesothelioma and a Potential Target for Asbestos-Related Cancer Therapy.Toxics · 2025Article
- An overview of BAP1 biological functions and current therapeutics.Biochimica et biophysica acta. Reviews on cancer · 2025Review
- Bayesian analysis of the rate of spontaneous malignant mesothelioma among BAP1 mutant mice in the absence of asbestos exposure.Scientific reports · 2025Article
- HDAC1: a promising target for cancer treatment: insights from a thorough analysis of tumor functions.Translational cancer research · 2024Article
- Long noncoding RNA AK144717 exacerbates pathological cardiac hypertrophy through modulating the cellular distribution of HMGB1 and subsequent DNA damage response.Cellular and molecular life sciences : CMLS · 2024Article
- Understanding the intersection between placental development and cancer: Lessons from the tumor suppressor BAP1.Communications biology · 2024Review
- Unraveling Novel Strategies in Mesothelioma Treatments Using a Newly Synthetized Platinum(IV) Compound.Pharmaceutics · 2024Article
- GermlineProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Identification of TNFRSF1A as a potential biomarker for osteosarcoma.Cancer biomarkers : section A of Disease markers · 2024Article
- Early-Onset Ovarian Cancer <30 Years: What Do We Know about Its Genetic Predisposition?International journal of molecular sciences · 2023Review
- Preventive and therapeutic opportunities: targeting BAP1 and/or HMGB1 pathways to diminish the burden of mesothelioma.Journal of translational medicine · 2023Review
- HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- BAP1 in cancer: epigenetic stability and genome integrity.Discover oncology · 2022Review
Corrections and comments
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Authors and funding
23 authors at 7 institutions in 4 countries.
Flavia NovelliThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.ORCID 0000-0002-3746-7478
Angela BononiThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.
Qian WangCenter for Theoretical Biological Physics, Rice University, Houston, TX 77005.
Fang BaiCenter for Theoretical Biological Physics, Rice University, Houston, TX 77005.
Simone PatergnaniDepartment of Medical Sciences, Laboratory for Technologies of Advanced Therapies, University of Ferrara, Ferrara 44121, Italy.ORCID 0000-0001-7951-9267
Franz KricekNBS-C BioScience & Consulting GmbH, Vienna 1230, Austria.
Ellinor HaglundDepartment of Chemistry, University of Hawaii, Honolulu, HI 96822.
Joelle S SuarezThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.ORCID 0000-0003-1528-2701
Mika TanjiThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.
Ronghui XuThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.ORCID 0000-0002-9842-2628
Yasutaka TakanishiThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.
Michael MinaaiThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.
Sandra PastorinoThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.
Paul MorrisThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.
Greg SakamotoThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.
Harvey I PassDepartment of Cardiothoracic Surgery, New York University, New York, NY 10016.
Haithem BarbourDepartment of Medicine, University of Montreal, Montreal, QC H1T 2M4, Canada.
Giovanni GaudinoThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816.ORCID 0000-0002-1572-6571
Carlotta GiorgiDepartment of Medical Sciences, Laboratory for Technologies of Advanced Therapies, University of Ferrara, Ferrara 44121, Italy.
Paolo PintonDepartment of Medical Sciences, Laboratory for Technologies of Advanced Therapies, University of Ferrara, Ferrara 44121, Italy.
Jose N OnuchicCenter for Theoretical Biological Physics, Rice University, Houston, TX 77005.ORCID 0000-0002-9448-0388
Haining YangThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816; mcarbone@cc.hawaii.edu haining@hawaii.edu.
Michele CarboneThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96816; mcarbone@cc.hawaii.edu haining@hawaii.edu.ORCID 0000-0001-8928-8474
University of Hawaiʻi at Mānoa · USUniversity of Ferrara · ITCenter for Theoretical Biological Physics · USNew York University · USUniversité de Montréal · CAUniversity of Hawaii System · USUniversity of Science and Technology of China · CN
Funding
The EDRN Mesothelioma Biomarker Discovery LaboratoryU01CA214195 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PASS, HARVEY IRA, YANG, HAINING · 2016 to 2021
$3.5MMechanisms of BAP1 activity in human cancer developmentR01CA237235 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI CARBONE, MICHELE, YANG, HAINING · 2020 to 2024
$2.1MInfluence of germline mutations on susceptibility to environmental carcinogensR01ES030948 · NIEHS · UNIVERSITY OF HAWAII AT MANOA · PI CARBONE, MICHELE, GRZYMSKI, JOSEPH J · 2019 to 2021
$1.9MGermline BAP1 Mutations and Malignant Mesothelioma: Mechanisms and Early DetectionR01CA198138 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI CARBONE, MICHELE · 2015 to 2019
$1.7MNCI NIH HHS R01 CA198138NCI NIH HHS R01 CA237235NCI NIH HHS U01 CA214195NIEHS NIH HHS R01 ES030948
Abstract
Carriers of heterozygous germline
Indexed as
AsbestosAnimalsBiomarkers, TumorCarcinogenesisCell NucleusFemaleGene-Environment InteractionGerm-Line MutationHeterozygoteHistone Deacetylase 1HMGB1 ProteinIncidenceInflammationMaleMesotheliomaMiceAsbestosBAP1 protein, mouseBiomarkers, TumorHdac1 protein, mouseHistone Deacetylase 1HMGB1 ProteinHMGB1 protein, mouseTumor Suppressor ProteinsUbiquitinUbiquitin Thiolesteraseasbestosgene × environmentgermline BAP1 mutationsHMGB1mesothelioma
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.