Evidence map›Paper›PMID 34815680›Full record

ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2021

Comparison of Antiobesity Effects of Adipose-Derived Stromal/Stem Cells from Different Sources in a Natural Aging Model.

Yu Zhu, Tao Wang, Shuangli He, Shiming Pu, Hongxia Zhao, Zuping Zhou, Qiong Wu

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. The Role of Renal Cell Senescence in Diabetic Kidney Disease: Mechanisms and Therapeutic Advances.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yu Zhu *School of Life Sciences, Guangxi Normal University, Guilin, Guangxi Zhuang Autonomous Region, People's Republic of China.
Tao Wang *School of Life Sciences, Guangxi Normal University, Guilin, Guangxi Zhuang Autonomous Region, People's Republic of China.
Shuangli HeSchool of Life Sciences, Guangxi Normal University, Guilin, Guangxi Zhuang Autonomous Region, People's Republic of China.
Shiming PuSchool of Life Sciences, Guangxi Normal University, Guilin, Guangxi Zhuang Autonomous Region, People's Republic of China.
Hongxia ZhaoSchool of Life Sciences, Guangxi Normal University, Guilin, Guangxi Zhuang Autonomous Region, People's Republic of China.
Zuping ZhouSchool of Life Sciences, Guangxi Normal University, Guilin, Guangxi Zhuang Autonomous Region, People's Republic of China.
Qiong WuSchool of Life Sciences, Guangxi Normal University, Guilin, Guangxi Zhuang Autonomous Region, People's Republic of China.
Guangxi Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOur previous study found that white adipose stem cells (W-ASCs) derived from abdominal and femoral sulcus white adipose stem cells (ASCs) have antiaging and age-related obesity effects. Whether interscapular brown adipose stem cells (B-ASCs) have the same effect has not been reported. The study objective was to compare the effects of ASCs from different tissues on aging and aging-related obesity. PATIENTS AND

methodsC57BL/6J mice at 22 months of age were transplanted with either B-ASCs or W-ASCs from young mice at 2 months of age. Changes in body weight, biochemistry, cytokines, hormone secretion, cell senescence, lipid metabolism, and ASC function were assessed after transplanted 1 month.

resultsW-ASCs were superior to B-ASCs as aging and age-related obesity indicators, based on change in body weight, organ weight, antioxidant and anti-inflammatory activity, lipid metabolism, and liver and kidney function.

conclusionDifference in the tissue source was reflected by the heterogeneity of antiaging and age-related obesity effects of transplanted ASCs. Based on the study results, we recommend W-ASCs over B-ASCs in aging and age-related obesity applications.

Indexed as

adipose-derived stromal/stem cellsagingdifferent tissue sourcesobesity

Identifiers

PMID34815680
PMCPMC8604647
OpenAlexW3211667638

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.