Evidence map›Paper›PMID 34815807›Full record

ArticleTheranostics2021

Extracellular vesicles fail to trigger the generation of new cardiomyocytes in chronically infarcted hearts.

Bruna Lima Correa, Nadia El Harane, Manon Desgres, Maria Perotto, Paul Alayrac, Chloé Guillas, Laetitia Pidial, Valérie Bellamy, Emilie Baron, Gwennhael Autret and 10 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05774509 (Treatment of Non-ischemic Dilated Cardiomyopathies by Intravenous Infusions of the Extracellular Vesicle-Enriched Secretome of Cardiovascular Progenitor Cells), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05774509 phase1active not recruitingnot on this mapstarted 2023, after this paper: background citation

Treatment of Non-ischemic Dilated Cardiomyopathies by Intravenous Infusions of the Extracellular Vesicle-Enriched Secretome of Cardiovascular Progenitor Cells

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2023 to 2027Enrolled11ConditionsHeart Failure With Reduced Ejection FractionArmsExtracellular vesicle-enriched secretome of cardiovascular progenitor cells differentiated from induced pluripotent stem cells
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  13. Extracellular vesicles: Targeting the heart.Frontiers in cardiovascular medicine · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Bruna Lima CorreaUniversité de Paris, PARCC, Inserm, F-75015 Paris, France.
Nadia El HaraneUniversity of Geneva, Translational Research Centre in Onco-hematology, Department of Medicine, Geneva, Switzerland.
Manon DesgresUniversité de Paris, PARCC, Inserm, F-75015 Paris, France.
Maria PerottoDepartment of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, Italy and Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Paul AlayracUniversité de Paris, PARCC, Inserm, F-75015 Paris, France.
Chloé GuillasUniversité de Paris, PARCC, Inserm, F-75015 Paris, France.
Laetitia PidialUniversité de Paris, PARCC, Inserm, F-75015 Paris, France.
Valérie BellamyUniversité de Paris, PARCC, Inserm, F-75015 Paris, France.
Emilie BaronDepartment of Cardiology, Hôpital Européen Georges Pompidou, F-75015 Paris, France.
Gwennhael AutretUniversité de Paris, PARCC, Inserm, F-75015 Paris, France.
Keirththana KamaleswaranUniversité de Paris, PARCC, Inserm, F-75015 Paris, France.
Chloé PezzanaUniversité de Paris, PARCC, Inserm, F-75015 Paris, France.
Marie-Cécile PerierUniversité de Paris, PARCC, Inserm, F-75015 Paris, France.
José VilarUniversité de Paris, PARCC, Inserm, F-75015 Paris, France.
Antonio AlberdiInserm, UMRS-976, Hôpital Saint-Louis, Paris, France.
Alain BrissonUMR-CBMN, Université de Bordeaux, CNRS, IPB, F-33600 Pessac, France.
Nisa RenaultFujifilm Cellular Dynamics, Inc, Madison, Wisconsin, USA.
Massimiliano GnecchiDepartment of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, Italy and Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Jean-Sébastien SilvestreUniversité de Paris, PARCC, Inserm, F-75015 Paris, France.
Philippe MenaschéUniversité de Paris, PARCC, Inserm, F-75015 Paris, France.
Inserm · FRUniversité Paris Cité · FRParis Cardiovascular Research Center · FRHôpital Saint-Louis · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCell- and Tissue-Based TherapyCell ProliferationCells, CulturedDisease Models, AnimalExtracellular VesiclesFibrosisGuided Tissue RegenerationHeart FailureHeart Function TestsHumansInduced Pluripotent Stem CellsMiceMice, TransgenicMicroRNAsMyocardial InfarctionMicroRNAs

Identifiers

PMID34815807
PMCPMC8581432
OpenAlexW3211444986

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.