Evidence map›Paper›PMID 34816032›Full record

ArticleHeliyon2021

High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines.

Chika Sawa, Sachiko Yofu, Keisuke Kiriyama, Keita Sutoh, Tomomi Saito, Satomi Kishi, Mariko Gunji, Yuriko Inoue, Masahito Sugi, Seiji Shioda and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Halogenated Boroxine KMolecules (Basel, Switzerland) · 2024
    Article
  4. New Perspectives on the Importance of Cell-Free DNA Biology.Diagnostics (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Chika SawaDepartment of Anatomy, Showa University, School of Medicine, Tokyo, Japan.
Sachiko YofuDepartment of Anatomy, Showa University, School of Medicine, Tokyo, Japan.
Keisuke KiriyamaFORDAYS Co., Ltd. Tokyo, Japan.
Keita SutohFORDAYS Co., Ltd. Tokyo, Japan.
Tomomi SaitoDepartment of Anatomy, Showa University, School of Medicine, Tokyo, Japan.
Satomi KishiDepartment of Anatomy, Showa University, School of Medicine, Tokyo, Japan.
Mariko GunjiDepartment of Anatomy, Showa University, School of Medicine, Tokyo, Japan.
Yuriko InoueDepartment of Anatomy, Showa University, School of Medicine, Tokyo, Japan.
Masahito SugiLife Science Institute Co., Ltd, Tokyo, Japan.
Seiji ShiodaDepartment of Anatomy and Physiology, Shonan University of Medical Sciences, Kanagawa, Japan.
Kazuho HondaDepartment of Anatomy, Showa University, School of Medicine, Tokyo, Japan.
Showa University · JPLife Science Institute · JPShonan University of Medical Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor necrosis frequently occurs in malignant tumors, showing rapid growth and invasion. This phenomenon is generally regarded as simple ischemic necrosis due to insufficient tumor vessels and blood supply. However, the necrotic tissue contains high amount of nuclear substances, DNA, and nucleoproteins that may affect the surrounding tumor cells by promoting or suppressing the tumor cell growth

Indexed as

Cell cycle delayCell proliferationExtracellular nucleotideNeutrophil extracellular trapsTumor necrosis

Identifiers

PMID34816032
PMCPMC8593434
OpenAlexW3214700392

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.