ArticleiScience2021
Resolving macrophage polarization through distinct Ca
Open access · goldAbstract read
In one paragraph
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The Role of TRP Channels in Colitis and Inflammatory Bowel Disease: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Dysferlin promotes inflammatory macrophage responses and modulates CaLife science alliance · 2026Article
- Ion channel/Stat6-driven nano-immune programming of tissue-resident macrophages by amide-functionalized nanocellulose.Bioactive materials · 2026Article
- Temporal immunomodulation of CD4Science advances · 2026Article
- Cation homeostasis-related prognostic genes uncovered by transcriptomic analysis in breast cancer.Translational cancer research · 2026Article
- Calcium Signaling in Macrophages During a Wound Response In Vivo.International journal of molecular sciences · 2026Article
- Article
- Implant-derived titanium particles impair macrophage bacterial clearance via TRPC1 and lysosomal dysfunction.PNAS nexus · 2026Article
- How do mechanical forces impact macrophages in the processes of mechanosensing and mechanotransduction?Journal of Zhejiang University. Science. B · 2025Review
- Intracellular Calcium as a Regulator of Polarization and Target Reprogramming of Macrophages.International journal of molecular sciences · 2025Review
- Amide-Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non-Small Cell Lung Adenocarcinoma.Advanced biology · 2025Article
- Physiological functions and pharmacological targeting of transient receptor potential channels.Pharmacological reviews · 2025Review
- Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitability.bioRxiv : the preprint server for biology · 2025Article
- Metallic nanomedicine in cancer immunotherapy.Acta pharmaceutica Sinica. B · 2025Review
- Reversion of a RND transporter pseudogene reveals latent stress resistance potential in Brucella ovis.PLoS genetics · 2025Article
- Is the SPLUNC1-Orai1 axis a critical determinant of lung health?Biochemical Society transactions · 2025Review
- The Role of mtDNA Mutations in Atherosclerosis: The Influence of Mitochondrial Dysfunction on Macrophage Polarization.International journal of molecular sciences · 2025Review
- Role of store-operated CaFrontiers in aging neuroscience · 2025Review
- 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice.Cell death discovery · 2024Article
- Comparative in vitro efficacy of antibiotics against the intracellular reservoir of Staphylococcus aureus.The Journal of antimicrobial chemotherapy · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 1 country.
Viviane Nascimento Da ConceicaoDepartment of Periodontics, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Yuyang SunDepartment of Periodontics, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Karthik RamachandranDepartment of Medicine, Cardiology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Arun ChauhanDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Amritha RaveendranDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Manigandan VenkatesanDepartment of Medicine, Cardiology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Bony DeKumarDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Soumya MaityDepartment of Medicine, Cardiology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Neelanjan VishnuDepartment of Medicine, Cardiology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
George A KotsakisDepartment of Periodontics, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Paul F WorleyDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Donald L GillDepartment of Cellular and Molecular Physiology, Penn State Hershey College of Medicine, Hershey, PA 17033, USA.
Bibhuti B MishraDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Muniswamy MadeshDepartment of Medicine, Cardiology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Brij B SinghDepartment of Periodontics, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
The University of Texas Health Science Center at San Antonio · USUniversity of North Dakota · USThe University of Texas at San Antonio · USJohns Hopkins Medicine · USPenn State Milton S. Hershey Medical Center · US
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1MInstitute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5MTRPC1, Calcium, and Saliva SecretionR01DE017102 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Brij B Singh · 2006 to 2026
$7.5MCoordination of Pathophysiologic Endothelial Cell Signaling by ROSR01HL086699 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2008 to 2018
$4.3MSpectral revelations of mitochondrial Ca2+ flux interactomeR01GM109882 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2014 to 2022
$3.3MUnderstanding Store-Operated Calcium Signal TransductionR35GM131916 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2019 to 2023
$2.9MControl of Endothelial Mechanotransduction by the Mitochondrial Ca2+ Uniporter: Implications for AtherosclerosisR01HL142673 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ALEVRIADOU, BARBARA RITA, MUNISWAMY, MADESH · 2018 to 2021
$2.0MEpigenetic regulations in Sjogern's syndromeR01DE022765 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SINGH, BRIJ B · 2017 to 2021
$1.8MEssential Role for SPG7 in Mitochondrial Permeability Transition Pore Assembly and FunctionR01GM135760 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2020 to 2021
$613kMultiphoton Confocal Microscopy for Biomedical ResearchS10RR027327 · NCRR · TEMPLE UNIV OF THE COMMONWEALTH · PI MUNISWAMY, MADESH · 2010 to 2010
$500kNCATS NIH HHS UL1 TR001120NCI NIH HHS P30 CA054174NCRR NIH HHS S10 RR027327NHLBI NIH HHS R01 HL086699NHLBI NIH HHS R01 HL142673NIDCR NIH HHS R01 DE017102NIDCR NIH HHS R01 DE022765NIGMS NIH HHS R01 GM109882NIGMS NIH HHS R01 GM135760NIGMS NIH HHS R35 GM131916
Abstract
Transformation of naive macrophages into classically (M1) or alternatively (M2) activated macrophages regulates the inflammatory response. Here, we identified that distinct Ca
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Immune systemMolecular biologyMolecular network
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What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.