Evidence map›Paper›PMID 34818036›Full record

ArticleScience advances2021

SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II.

Richard King, Zesen Lin, Ginette Balbin-Cuesta, Gregg Myers, Ann Friedman, Guojing Zhu, Beth McGee, Thomas L Saunders, Ryo Kurita, Yukio Nakamura and 3 more

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Hereditary disorders of ineffective erythropoiesis.Blood cells, molecules & diseases · 2025
    Review
  5. Article
  6. Article
  7. Functional overlap between the mammalianProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Functional overlap between the mammalianbioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Richard KingDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-0519-8776
Zesen LinDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, USA.
Ginette Balbin-CuestaCellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA.
Gregg MyersDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-2810-8091
Ann FriedmanDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-4915-4038
Guojing ZhuLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Beth McGeeDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-5786-7164
Thomas L SaundersDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-2015-101X
Ryo KuritaDepartment of Research and Development, Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
Yukio NakamuraCell Engineering Division, RIKEN BioResource Research Center, Ibaraki, Japan.
James Douglas EngelDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Pavan ReddyDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-7264-8429
Rami KhoriatyDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-2539-5953

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
Targeting Enzymatic Regulation of Fetal Hemoglobin RepressionP01HL146372 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ENGEL, JAMES DOUGLAS · 2019 to 2023
$10.9M
ONCOLOGY RESEARCH TRAINING GRANTT32CA009357 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Qing Li · 1987 to 2026
$8.6M
University of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1M
The molecular pathophysiology of the congenital dyserythropoietic anemiasR01HL148333 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Rami Khoriaty · 2019 to 2026
$4.6M
COPII dependent regulation of T cell alloimmunityR01HL152605 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REDDY, PAVAN · 2020 to 2023
$2.4M
The regulation of thrombopoietin levelsR01HL157062 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KHORIATY, RAMI · 2021 to 2024
$2.1M
NCI NIH HHS P30 CA046592NCI NIH HHS T32 CA009357NHLBI NIH HHS P01 HL146372NHLBI NIH HHS R01 HL148333NHLBI NIH HHS R01 HL152605NHLBI NIH HHS R01 HL157062NIGMS NIH HHS R25 GM086262NIGMS NIH HHS T32 GM007315NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

Congenital dyserythropoietic anemia type II (CDAII) results from loss-of-function mutations in

Identifiers

PMID34818036
PMCPMC8612686

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.