ArticleScience advances2021
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies.
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In one paragraph
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
What it found
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Proteolytic shedding of the prion protein: Uncovering "new" biological implications of a conserved cleavage event.Neural regeneration research · 2026Article
- Programmable CRISPR-Cas diagnostic platforms for rapid detection of uropathogens and antimicrobial resistance.Archives of microbiology · 2026Review
- ADAM10-Mediated Proteolytic Remodelling of Signalling and Adhesion Proteins on Brain Cell-Derived Small Extracellular Vesicles.Journal of extracellular biology · 2026Article
- D178N prion protein mutation endows RML prions with new strain properties that do not mimic human genetic prion diseases.Acta neuropathologica · 2026Article
- Saliva-based molecular diagnostics in oral squamous cell carcinoma (OSCC): a non-invasive frontier in oncology.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Review
- Therapeutic Trajectories in Human Prion Diseases.Sub-cellular biochemistry · 2025Review
- Prion protein alters viral control and enhances pathology after perinatal cytomegalovirus infection.Nature communications · 2024Article
- Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.Acta neuropathologica · 2024Article
- Post-translational modifications in prion diseases.Frontiers in molecular neuroscience · 2024Review
- New implications for prion diseases therapy and prophylaxis.Frontiers in molecular neuroscience · 2024Review
- A tetracationic porphyrin with dual anti-prion activity.iScience · 2023Article
- Inducing prion protein shedding as a neuroprotective and regenerative approach in pathological conditions of the brain: from theory to facts.Neural regeneration research · 2023Review
- Anchorless risk or released benefit? An updated view on the ADAM10-mediated shedding of the prion protein.Cell and tissue research · 2023Review
- Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity.Brain pathology (Zurich, Switzerland) · 2023Article
- Prion Protein: The Molecule of Many Forms and Faces.International journal of molecular sciences · 2022Review
- Bioinformatics and System Biology Techniques to Determine Biomolecular Signatures and Pathways of Prion Disorder.Bioinformatics and biology insights · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 11 institutions in 6 countries.
Luise LinsenmeierInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.ORCID 0000-0002-4680-7622
Behnam MohammadiInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.ORCID 0000-0002-9178-3949
Mohsin ShafiqInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.ORCID 0000-0002-4974-8955
Karl FrontzekInstitute of Neuropathology, University of Zurich, Zürich, Switzerland.ORCID 0000-0002-0945-8857
Julia BärInstitute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
Amulya N ShrivastavaÉcole Normale Supérieure, Institut de Biologie de l'ENS (IBENS), INSERM, CNRS, PSL Research University, Paris, France.ORCID 0000-0002-1322-8018
Markus DammeInstitute of Biochemistry, Christian Albrechts University, Kiel, Germany.
Feizhi SongInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Alexander SchwarzInstitute of Nanostructure and Solid State Physics, Universität Hamburg, Hamburg, Germany.ORCID 0000-0002-9700-9129
Stefano Da VelaEuropean Molecular Biology Laboratory (EMBL), Hamburg, Germany.ORCID 0000-0002-1700-4759
Tania MassignanDulbecco Telethon Laboratory of Prions and Amyloids, CIBIO, University of Trento, Trento, Italy.ORCID 0000-0002-6176-2696
Sebastian JungDepartment Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0002-0365-5710
Angela CorreiaDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Matthias SchmitzDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0002-5502-681X
Berta PuigDepartment of Neurology, Experimental Research in Stroke and Inflammation, UKE, Hamburg, Germany.ORCID 0000-0002-2255-8393
Simone HornemannInstitute of Neuropathology, University of Zurich, Zürich, Switzerland.ORCID 0000-0002-2674-9891
Inga ZerrDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Jörg TatzeltDepartment Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0001-5017-5528
Emiliano BiasiniDulbecco Telethon Laboratory of Prions and Amyloids, CIBIO, University of Trento, Trento, Italy.
Paul SaftigInstitute of Biochemistry, Christian Albrechts University, Kiel, Germany.
Michaela SchweizerCenter for Molecular Neurobiology Hamburg (ZMNH), UKE, Hamburg, Germany.
Dmitri SvergunEuropean Molecular Biology Laboratory (EMBL), Hamburg, Germany.ORCID 0000-0003-0830-5696
Ladan AminDepartment of Biochemistry, Boston University School of Medicine, Boston, MA, USA.ORCID 0000-0001-6388-8869
Federica MazzolaInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Luca VaraniInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.ORCID 0000-0002-0963-0987
Simrika ThapaCalgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.
Sabine GilchCalgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.
Hermann SchätzlCalgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0003-4972-8740
David A HarrisDepartment of Biochemistry, Boston University School of Medicine, Boston, MA, USA.ORCID 0000-0002-6985-5790
Antoine TrillerÉcole Normale Supérieure, Institut de Biologie de l'ENS (IBENS), INSERM, CNRS, PSL Research University, Paris, France.
Marina MikhaylovaInstitute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
Adriano AguzziInstitute of Neuropathology, University of Zurich, Zürich, Switzerland.ORCID 0000-0002-0344-6708
Hermann C AltmeppenInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.ORCID 0000-0001-9439-6533
Markus GlatzelInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.ORCID 0000-0002-7720-8817
Universität Hamburg · DEUniversitätsmedizin Göttingen · DEUniversity of Calgary · CAUniversity of Zurich · CHBoston University · USCentre National de la Recherche Scientifique · FRChristian-Albrechts-Universität zu Kiel · DEEuropean Molecular Biology Laboratory · DERuhr University Bochum · DEUniversità della Svizzera italiana · CHUniversity of Trento · IT
Funding
Mechanisms of Prion Protein ToxicityR01NS065244 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HARRIS, DAVID A · 2010 to 2025
$8.9MResource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2MNIGMS NIH HHS P41 GM103311NINDS NIH HHS R01 NS065244
Abstract
The prion protein (PrP
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.