Evidence map›Paper›PMID 34819367›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth.

Tomas Raul Wiche Salinas, Yuwei Zhang, Daniele Sarnello, Alexander Zhyvoloup, Laurence Raymond Marchand, Augustine Fert, Delphine Planas, Manivel Lodha, Debashree Chatterjee, Katarzyna Karwacz and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

  1. HCV-specific CD4EBioMedicine · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Frontiers in immunology · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. A Transcriptomic Analysis of Laryngeal Dysplasia.International journal of molecular sciences · 2024
    Review
  13. Article
  14. Article
  15. The Complex Dysregulations of CD4 T Cell Subtypes in HIV Infection.International journal of molecular sciences · 2024
    Review
  16. Metformin Enhances Antibody-Mediated Recognition of HIV-Infected CD4bioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Targeting HIV-1 reservoirs in T cell subsets.Frontiers in immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Tomas Raul Wiche SalinasCentre de recherche du Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, QC H2X 0A9, Canada.ORCID 0000-0001-8806-4700
Yuwei ZhangCentre de recherche du Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, QC H2X 0A9, Canada.
Daniele SarnelloInstitute of Immunity and Transplantation, University College London, London NW3 2QG, United Kingdom.ORCID 0000-0003-4193-2464
Alexander ZhyvoloupInstitute of Immunity and Transplantation, University College London, London NW3 2QG, United Kingdom.
Laurence Raymond MarchandCentre de recherche du Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, QC H2X 0A9, Canada.
Augustine FertCentre de recherche du Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, QC H2X 0A9, Canada.
Delphine PlanasCentre de recherche du Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, QC H2X 0A9, Canada.
Manivel LodhaInstitute of Immunity and Transplantation, University College London, London NW3 2QG, United Kingdom.ORCID 0000-0002-0258-1895
Debashree ChatterjeeCentre de recherche du Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, QC H2X 0A9, Canada.
Katarzyna KarwaczInstitute of Immunity and Transplantation, University College London, London NW3 2QG, United Kingdom.
Sally OxenfordTranslational Research Office-Medicinal Chemistry, University College London School of Pharmacy, London WC1N 1AX, United Kingdom.
Jean-Pierre RoutyDivision of Hematology and Chronic Viral Illness Service, McGill University Medical Centre, Montréal, QC H4A 3J1, Canada.ORCID 0000-0001-9897-7589
David IrlbeckViiV Healthcare, Research Triangle Park, NC 27709-3398.ORCID 0000-0002-8852-9261
Heather Amrine-MadsenViiV Healthcare, Research Triangle Park, NC 27709-3398.
Petronela AncutaCentre de recherche du Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, QC H2X 0A9, Canada; a.fassati@ucl.ac.uk petronela.ancuta@umontreal.ca.ORCID 0000-0003-1922-5640
Ariberto FassatiInstitute of Immunity and Transplantation, University College London, London NW3 2QG, United Kingdom; a.fassati@ucl.ac.uk petronela.ancuta@umontreal.ca.
Centre Hospitalier de l’Université de Montréal · CAUniversity College London · GBTriangle · USMcGill University Health Centre · CA

Funding

CIHR HB2-164064CIHR MOP 103230CIHR PJT NO. 153052CIHR PTJ 166049
6 · The paper itself

Abstract

Among CD4

Indexed as

AdultCD4-Positive T-LymphocytesCell DifferentiationCytokinesFemaleGene ExpressionGene Expression Regulation, ViralHIV-1HIV InfectionsHumansLymphocyte ActivationMaleMiddle AgedNuclear Receptor Subfamily 1, Group F, Member 3Primary Cell CultureTh17 CellsCytokinesNuclear Receptor Subfamily 1, Group F, Member 3RORC protein, humanTranscription Factorsgene expressionHIV-1hormone receptorRORC2Th17

Identifiers

PMID34819367
PMCPMC8640723
OpenAlexW3216073603

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.