Evidence map›Paper›PMID 34819390›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Stereotypic Expansion of T Regulatory and Th17 Cells during Infancy Is Disrupted by HIV Exposure and Gut Epithelial Damage.

Sonwabile Dzanibe, Katie Lennard, Agano Kiravu, Melanie S S Seabrook, Berenice Alinde, Susan P Holmes, Catherine A Blish, Heather B Jaspan, Clive M Gray

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sonwabile DzanibeDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa; s.dzanibe@uct.ac.za cgray@sun.ac.za.ORCID 0000-0001-5738-8438
Katie LennardDivision of Computational Biology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Agano KiravuDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-2510-2479
Melanie S S SeabrookDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-0490-1466
Berenice AlindeDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-3240-8014
Susan P HolmesDepartment of Statistic, Stanford University, Stanford, CA.ORCID 0000-0002-2208-8168
Catherine A BlishDepartment of Medicine, School of Medicine, Stanford University, Stanford, CA.ORCID 0000-0001-6946-7627
Heather B JaspanDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-0745-6073
Clive M GrayDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa; s.dzanibe@uct.ac.za cgray@sun.ac.za.ORCID 0000-0002-9293-901X

Funding

Impact of HIV exposure, feeding status, and microbiome on immune ontogeny and vaccine responses in infantsU01AI131302 · NIAID · STANFORD UNIVERSITY · PI BLISH, CATHERINE A, GRAY, CLIVE MAURICE · 2017 to 2021
$2.1M
MECHANISMS LEADING TO ADVERSE BIRTH OUTCOMES IN SOUTH AFRICAN HIV-INFECTED WOMENR01HD102050 · NICHD · UNIVERSITY OF CAPE TOWN · PI GRAY, CLIVE MAURICE, JASPAN, HEATHER BERYL · 2020 to 2024
$1.7M
Mechanisms of altered immune responses in HIV exposed infantsR21HD083344 · NICHD · UNIVERSITY OF CAPE TOWN · PI GRAY, CLIVE MAURICE, JASPAN, HEATHER BERYL · 2015 to 2016
$415k
Mechanisms by which trophoblasts recruit T cells to the placental villi during maternal HIV and CMV co-infectionR21HD103498 · NICHD · MAYO CLINIC ROCHESTER · PI CHAKRABORTY, RANA, GRAY, CLIVE MAURICE · 2020 to 2021
$390k
NIAID NIH HHS U01 AI131302NICHD NIH HHS R01 HD102050NICHD NIH HHS R21 HD083344NICHD NIH HHS R21 HD103498
6 · The paper itself

Abstract

Few studies have investigated immune cell ontogeny throughout the neonatal and early pediatric period, when there is often increased vulnerability to infections. In this study, we evaluated the dynamics of two critical T cell populations, T regulatory (Treg) cells and Th17 cells, over the first 36 wk of human life. First, we observed distinct CD4

Indexed as

Cell ProliferationChild, PreschoolFemaleHIV-1HIV InfectionsHomeostasisHumansInfantInfant, NewbornIntestinal MucosaLymphocyte ActivationLymphopeniaMalePregnancyPrenatal Exposure Delayed EffectsTh17 Cells

Identifiers

PMID34819390
PMCPMC8702481

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.