Evidence map›Paper›PMID 34820603›Full record

ArticleiScience2021

Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure.

Amelia K Fotheringham, Samantha M Solon-Biet, Helle Bielefeldt-Ohmann, Domenica A McCarthy, Aisling C McMahon, Kari Ruohonen, Isaac Li, Mitchell A Sullivan, Rani O Whiddett, Danielle J Borg and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Amelia K FotheringhamGlycation and Diabetes Complications Group, Mater Research Institute-The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, Brisbane 4072, QLD, Australia.
Samantha M Solon-BietCharles Perkins Centre, University of Sydney, Sydney 2006, NSW, Australia.
Helle Bielefeldt-OhmannSchool of Veterinary Science, University of Queensland, Gatton Campus, Gatton 4343, QLD, Australia.
Domenica A McCarthyGlycation and Diabetes Complications Group, Mater Research Institute-The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, Brisbane 4072, QLD, Australia.
Aisling C McMahonCharles Perkins Centre, University of Sydney, Sydney 2006, NSW, Australia.
Kari RuohonenAnimal Nutrition and Health, Cargill, Sandnes, Norway.
Isaac LiFaculty of Medicine, University of Queensland, Brisbane 4067, QLD, Australia.
Mitchell A SullivanGlycation and Diabetes Complications Group, Mater Research Institute-The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, Brisbane 4072, QLD, Australia.
Rani O WhiddettGlycation and Diabetes Complications Group, Mater Research Institute-The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, Brisbane 4072, QLD, Australia.
Danielle J BorgGlycation and Diabetes Complications Group, Mater Research Institute-The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, Brisbane 4072, QLD, Australia.
Victoria C CoggerCharles Perkins Centre, University of Sydney, Sydney 2006, NSW, Australia.
William O BallardSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 2052, NSW, Australia.
Nigel TurnerDepartment of Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales Sydney, NSW 2052, Australia.
Richard G MelvinDepartment of Biomedical Sciences, University of Minnesota Medical School, 1035 University Drive, Duluth 55812, MN, USA.
David RaubenheimerCharles Perkins Centre, University of Sydney, Sydney 2006, NSW, Australia.
David G Le CouteurCharles Perkins Centre, University of Sydney, Sydney 2006, NSW, Australia.
Stephen J SimpsonCharles Perkins Centre, University of Sydney, Sydney 2006, NSW, Australia.
Josephine M ForbesGlycation and Diabetes Complications Group, Mater Research Institute-The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, Brisbane 4072, QLD, Australia.
The University of Sydney · AUTranslational Research Institute · AUThe University of Queensland · AUUNSW Sydney · AUUniversity of Minnesota, Duluth · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The kidneys balance many byproducts of the metabolism of dietary components. Previous studies examining dietary effects on kidney health are generally of short duration and manipulate a single macronutrient. Here, kidney function and structure were examined in C57BL/6J mice randomized to consume one of a spectrum of macronutrient combinations (protein [5%-60%], carbohydrate [20%-75%], and fat [20%-75%]) from weaning to late-middle age (15 months). Individual and interactive impacts of macronutrients on kidney health were modeled. Dietary protein had the greatest influence on kidney function, where chronic low protein intake decreased glomerular filtration rates and kidney mass, whereas it increased kidney immune infiltration and structural injury. Kidney outcomes did not align with cardiometabolic risk factors including glucose intolerance, overweight/obesity, dyslipidemia, and hypertension in mice with chronic low protein consumption. This study highlights that protein intake over a lifespan is an important determinant of kidney function independent of cardiometabolic changes.

Indexed as

Animal physiologyMetabolomicsPhysiologySystems biology

Identifiers

PMID34820603
PMCPMC8602032
OpenAlexW3205180325

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.