Evidence map›Paper›PMID 34827683›Full record

ArticleBiomolecules2021

Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease.

Katrīna D Neiburga, Baiba Vilne, Sabine Bauer, Dario Bongiovanni, Tilman Ziegler, Mark Lachmann, Simon Wengert, Johann S Hawe, Ulrich Güldener, Annie M Westerlund and 11 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  9. MicroRNA Profiling in Chronic Limb-Threatening Ischemia Their Role in Arteriogenesis.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 3 countries.

Katrīna D NeiburgaBioinformatics Lab, Riga Stradiņš University, LV-1007 Riga, Latvia.ORCID 0000-0002-4731-7596
Baiba VilneBioinformatics Lab, Riga Stradiņš University, LV-1007 Riga, Latvia.ORCID 0000-0002-1084-7067
Sabine BauerGerman Heart Centre Munich, Department of Cardiology, Technical University Munich, 80636 Munich, Germany.ORCID 0000-0001-7929-8417
Dario BongiovanniDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80802 Munich, Germany.ORCID 0000-0002-4162-1482
Tilman ZieglerDepartment of Internal Medicine I, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
Mark LachmannDepartment of Internal Medicine I, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
Simon WengertHelmholtz Pioneer Campus, Helmholtz Zentrum München, 85764 Neuherberg, Germany.ORCID 0000-0003-1271-1996
Johann S HaweGerman Heart Centre Munich, Department of Cardiology, Technical University Munich, 80636 Munich, Germany.
Ulrich GüldenerGerman Heart Centre Munich, Department of Cardiology, Technical University Munich, 80636 Munich, Germany.ORCID 0000-0001-5052-8610
Annie M WesterlundGerman Heart Centre Munich, Department of Cardiology, Technical University Munich, 80636 Munich, Germany.ORCID 0000-0003-2288-5711
Ling LiGerman Heart Centre Munich, Department of Cardiology, Technical University Munich, 80636 Munich, Germany.
Shichao PangGerman Heart Centre Munich, Department of Cardiology, Technical University Munich, 80636 Munich, Germany.
Chuhua YangGerman Heart Centre Munich, Department of Cardiology, Technical University Munich, 80636 Munich, Germany.
Kathrin SaarMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
Norbert HuebnerMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
Lars MaegdefesselDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80802 Munich, Germany.
DigiMed Bayern Consortium
Rüdiger LangeDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80802 Munich, Germany.
Markus KraneDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80802 Munich, Germany.
Heribert SchunkertGerman Heart Centre Munich, Department of Cardiology, Technical University Munich, 80636 Munich, Germany.
Moritz von ScheidtGerman Heart Centre Munich, Department of Cardiology, Technical University Munich, 80636 Munich, Germany.ORCID 0000-0001-7159-8271
Deutsches Herzzentrum München · DETUM Klinikum · DEGerman Centre for Cardiovascular Research · DEHelmholtz Zentrum München · DEMax Delbrück Center · DERiga Stradiņš University · LVYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression. While microRNAs (miRs) have been well studied in blood samples, there is little data on tissue-specific miRs in cardiovascular relevant tissues and their relation to cardiovascular risk factors. Tissue-specific miRs derived from

Indexed as

Coronary Artery DiseaseMicroRNAsAgedBiomarkersCoronary Artery BypassFemaleGene Expression ProfilingHumansMaleMiddle AgedRisk FactorsBiomarkersMicroRNAsarteria mammaria internabiomarkerbiosensorcardiovascular diseasecoronary artery bypass graftingcoronary artery diseaselocal therapymicro RNApersonalized medicine

Identifiers

PMID34827683
PMCPMC8615466
OpenAlexW3213829310

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.