Evidence mapPaperPMID 34827690Full record

ReviewBiomolecules2021

Advanced Bioinformatics Tools in the Pharmacokinetic Profiles of Natural and Synthetic Compounds with Anti-Diabetic Activity.

Ana Maria Udrea, Gratiela Gradisteanu Pircalabioru, Anca Andreea Boboc, Catalina Mares, Andra Dinache, Maria Mernea, Speranta Avram

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  6. Article
  7. Therapeutic Potential of Momordicine I fromInternational journal of molecular sciences · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ana Maria UdreaLaser Department, National Institute for Laser, Plasma and Radiation Physics, 077125 Maurele, Romania.ORCID 0000-0002-7659-7435
Gratiela Gradisteanu PircalabioruEarth, Environmental and Life Sciences Section, Research Institute of the University of Bucharest, University of Bucharest, 1 B. P. Hașdeu St., 50567 Bucharest, Romania.
Anca Andreea Boboc"Maria Sklodowska Curie" Emergency Children's Hospital, 20, Constantin Brancoveanu Bd., 077120 Bucharest, Romania.
Catalina MaresDepartment of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania.
Andra DinacheLaser Department, National Institute for Laser, Plasma and Radiation Physics, 077125 Maurele, Romania.ORCID 0000-0001-6107-7675
Maria MerneaDepartment of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania.
Speranta AvramDepartment of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania.
University of Bucharest · ROCarol Davila University of Medicine and Pharmacy · RONational Institute for Laser Plasma and Radiation Physics · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes represents a major health problem, involving a severe imbalance of blood sugar levels, which can disturb the nerves, eyes, kidneys, and other organs. Diabes management involves several synthetic drugs focused on improving insulin sensitivity, increasing insulin production, and decreasing blood glucose levels, but with unclear molecular mechanisms and severe side effects. Natural chemicals extracted from several plants such as

Indexed as

Blood-Brain BarrierComputational BiologyHypoglycemic AgentsAnimalsBiological ProductsDiabetes MellitusHumansMolecular Docking SimulationQuantitative Structure-Activity RelationshipBiological ProductsHypoglycemic Agentsblood–brain barrierdiabetes mellitusin silicomolecular dockingmolecular dynamicsnatural compoundsQSAR

Identifiers

PMID34827690
PMCPMC8615418
OpenAlexW3214310319

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.