Evidence map›Paper›PMID 34827893›Full record

ArticleAnimals : an open access journal from MDPI2021

Association of Melatonin Administration in Pregnant Ewes with Growth, Redox Status and Immunity of Their Offspring.

Efterpi Bouroutzika, Maria Giovanna Ciliberti, Mariangela Caroprese, Ekaterini Theodosiadou, Serafeim Papadopoulos, Sotiria Makri, Zoi-Vasiliki Skaperda, Georgios Kotsadam, Marios-Lazaros Michailidis, George Valiakos and 3 more

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Melatonin in animal husbandry: functions and applications.Frontiers in veterinary science · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Efterpi BouroutzikaFaculty of Veterinary Science, University of Thessaly, 43100 Karditsa, Greece.
Maria Giovanna CilibertiDepartment of Agriculture, Food, Natural Resources, and Engineering (DAFNE), University of Foggia, 71122 Foggia, Italy.ORCID 0000-0003-2296-2991
Mariangela CaropreseDepartment of Agriculture, Food, Natural Resources, and Engineering (DAFNE), University of Foggia, 71122 Foggia, Italy.ORCID 0000-0002-5292-3291
Ekaterini TheodosiadouFaculty of Veterinary Science, University of Thessaly, 43100 Karditsa, Greece.
Serafeim PapadopoulosDepartment of Ichthyology and Aquatic Environment, University of Thessaly, 38446 Volos, Greece.ORCID 0000-0001-9294-1067
Sotiria MakriDepartment of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece.
Zoi-Vasiliki SkaperdaDepartment of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece.ORCID 0000-0001-5251-4925
Georgios KotsadamFaculty of Veterinary Science, University of Thessaly, 43100 Karditsa, Greece.
Marios-Lazaros MichailidisFaculty of Veterinary Science, University of Thessaly, 43100 Karditsa, Greece.
George ValiakosFaculty of Veterinary Science, University of Thessaly, 43100 Karditsa, Greece.ORCID 0000-0002-3869-5026
Stella ChadioDepartment of Animal Science, Agricultural University of Athens, 11855 Athens, Greece.
Dimitris KouretasDepartment of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece.ORCID 0000-0002-7469-6640
Irene ValasiFaculty of Veterinary Science, University of Thessaly, 43100 Karditsa, Greece.
University of Thessaly · GRUniversity of Foggia · ITAgricultural University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, the effects of melatonin treatment on growth, redox status and immunity in prenatally stressed newborn lambs were evaluated. Thirty-seven newborn lambs were allocated into two groups (melatonin-MEL and control-CON), based on whether their mothers were treated with melatonin implants or not, respectively. All pregnant ewes were exposed to heat stress. The body weight of lambs was recorded at birth (L0), and then on days 15 (L15) and 40 (L40). Redox biomarkers [total antioxidant capacity (TAC), glutathione (GSH), thiobarbituric acid reactive substances (TBARS)] were assayed in blood samples collected from lambs on days L0, L1, L2, L5, L10 and L40. Chemical analysis and antioxidant capacity were evaluated in colostrum and milk samples collected at the same time points with blood samples. Cytokines (IL-1β, IL-6, IL-10, IFN-γ) and immunoglobulin (IgG) were assayed in blood and colostrum samples collected from ewes on days L0 and L1, and in lambs' blood on days L0, L1 and L2. The results revealed that body weight gain of newborn lambs did not differ between the two groups (

Indexed as

antioxidant biomarkerscytokinesIgGlambsmelatoninprenatal stress

Identifiers

PMID34827893
PMCPMC8614450
OpenAlexW3212535097

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.